Titagen® for total wellness: results from a randomised, placebo controlled clinical study on adults for osteoarthritis, improvement in skin, nail and health

Sriraam V. T.; Shakthi S.; Raja Singla; Shivom Singla

doi:10.18203/2320-6012.ijrms20253965

Authors

Sriraam V. T. Aurous HealthCare Research and Development India Pvt. Ltd., Kodambakkam, Chennai, Tamil Nadu, India https://orcid.org/0009-0000-1221-4303
Shakthi S. Aurous HealthCare Research and Development India Pvt. Ltd., Kodambakkam, Chennai, Tamil Nadu, India https://orcid.org/0009-0001-0866-929X
Raja Singla Titan Biotech Limited, Netaji Subhash Place, Delhi, New Delhi, India
Shivom Singla Titan Biotech Limited, Netaji Subhash Place, Delhi, New Delhi, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20253965

Keywords:

Collagen peptide, Fish Collagen, Collagen for osteoarthritis, Collagen for skin, Collagen for nails, Collagen for hair

Abstract

Background: Fish collagen has been vital in functional food with natural bioactive compounds to offer potential therapeutic benefits. Titan biotech limited (TBL) has studied Titagen® as a nutraceutical to evaluate improvement in in adults looking to improve skin, hair, nail health and osteoarthritis.

Methods: Two randomised, double blinded, placebo controlled clinical studies were conducted on Titagen® of TBL. 48 adults were studied in each of the studies for a period of 90 days. Study 1 (SHN study) was conducted on adults looking to improve skin, hair and nail health with Titagen® dose of 5g per day for 3 months-assessed, using assessments and questionnaire to evaluate skin improvement, hair growth and nail health. Study 2 (OA study) was conducted on adults with osteoarthritis with Titagen® dose of 10 g per day for 3 months-evaluated using assessments and questionnaires.

Results: Results showed that Titagen® was better than placebo with statistically significant results in skin health (59.72% vs -51.39), 60 second hair comb test (27.15% vs 2.35%), hair health (18.06% vs -43.06%), nail health (62.50% vs -33.33%), Western Ontario and McMaster universities arthritis index (WOMAC) parameters (39.73% vs 1.72%), pain VAS (70.86% vs 4.21%), quality of life questionnaire (20.83 scores vs 7.31 scores), global impression of change scale results (2.75 vs 4.40). There were no adverse events related to Titagen® and is deemed safe for daily consumption.

Conclusions: The clinical studies proved 5 g Titagen® for 90 days improved skin, hair and nail health, 10 g Titagen® for 90 days reduced pain, stiffness in joints and improved quality of life living with osteoarthritis.

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References

Shinde, Namdeo. Nutraceuticals: A Review on current status. Res J Pharmacy Technol. 2014;7(1):110-3.

Yamada S, Yamamoto K, Nakazono A, Matsuura T, Yoshimura A. Functional roles of fish collagen peptides on bone regeneration. Dental Materials J. 2021;40(6):1295-302. DOI: https://doi.org/10.4012/dmj.2020-446

Cadar E, Pesterau A-M, Prasacu I, Ionescu A-M, Pascale C, Dragan A-ML, et al. Marine Antioxidants from Marine Collagen and Collagen Peptides with Nutraceuticals Applications: A Review. Antioxidants. 2024;13(8):919. DOI: https://doi.org/10.3390/antiox13080919

Venkatesan J, Anil S, Kim S-K, Shim M. Marine Fish Proteins and Peptides for Cosmeceuticals: A Review. Marine Drugs. 2017;15(5):143. DOI: https://doi.org/10.3390/md15050143

Salvatore L, Gallo N, Natali ML, Campa L, Lunetti P, Madaghiele M, et al. Marine collagen and its derivatives: Versatile and sustainable bio-resources for healthcare. Materials Sci Engineering: C. 2020;113:110963. DOI: https://doi.org/10.1016/j.msec.2020.110963

Cho W, Park J, Kim J, Lee M, Park SJ, Kim KS, et al. Low-Molecular-Weight Fish Collagen Peptide (Valine-Glycine-Proline-Hydroxyproline-Glycine-Proline-Alanine-Glycine) Prevents Osteoarthritis Symptoms in Chondrocytes and Monoiodoacetate-Injected Rats. Marine Drugs. 2023;21(12):608. DOI: https://doi.org/10.3390/md21120608

Geahchan S, Baharlouei P, Rahman A. Marine Collagen: A Promising Biomaterial for Wound Healing, Skin Anti-Aging, and Bone Regeneration. Marine Drugs. 2022;20(1):61. DOI: https://doi.org/10.3390/md20010061

Lacey S. Effect Size Statistics to Inform an Exploratory Analysis of a Double-Blinded, Randomised, Placebo Controlled Pilot Clinical Study to Evaluate the Efficacy of Naticol®, Specific Fish Collagen Peptides to Alleviate Symptoms of Osteoarthritis in the Knee. Juniper Online J Case Studies. 2019;10(2):30-7. DOI: https://doi.org/10.19080/JOJCS.2018.09.555783

Wasko CA, Mackley CL, Sperling LC, Mauger D, Miller JJ. Standardizing the 60-Second Hair Count. Arch Dermatol. 2008;144(6):759-62. DOI: https://doi.org/10.1001/archderm.144.6.759

Bellamy N, Buchanan WW. A preliminary evaluation of the dimensionality and clinical importance of pain and disability in osteoarthritis of the hip and knee. Clin Rheumatol. 1986;5(2):231-41. DOI: https://doi.org/10.1007/BF02032362

Salaffi F, Stancati A, Silvestri CA, Ciapetti A, Grassi W. Minimal clinically important changes in chronic musculoskeletal pain intensity measured on a numerical rating scale. Europ J Pain. 2004;8(4):283-91. DOI: https://doi.org/10.1016/j.ejpain.2003.09.004

García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, et al. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthopaedics. 2018;43(3):531-8. DOI: https://doi.org/10.1007/s00264-018-4211-5

Kim D-U, Chung H-C, Choi J, Sakai Y, Lee B-Y. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 2018;10(7):826. DOI: https://doi.org/10.3390/nu10070826

Lin C-R, Tsai SHL, Huang K-Y, Tsai P-A, Chou H, Chang S-H. Analgesic efficacy of collagen peptide in knee osteoarthritis: a meta-analysis of randomized controlled trials. J Orthopaed Surg Res. 2023;18(1):694. DOI: https://doi.org/10.1186/s13018-023-04182-w

Oesser S, Schulze CH, Zdzieblik D, König D. Efficacy of specific bioactive collagen peptides in the treatment of joint pain. Osteoarthritis Cartilage. 2016;24:S189. DOI: https://doi.org/10.1016/j.joca.2016.01.370

Jiang JX, Yu S, Huang QR, Zhang XL, Zhang CQ, Zhou JL, et al. Collagen peptides improve knee osteoarthritis in elderly women: A 6-month randomized, double-blind, placebo-controlled study. Agro Food Industry Hi Tech. 2014;25(2):19-23.

Scarpellini M, Lurati A, Vignati G, Marrazza MG, Telese F, Re K, et al. Biomarkers, type II collagen, glucosamine and chondroitin sulfate in osteoarthritis follow-up: the "Magenta osteoarthritis study". J Orthop Traumatol. 2008;9(2):81-7. DOI: https://doi.org/10.1007/s10195-008-0007-5

Reilly DM, Kynaston L, Naseem S, Proudman E, Laceby D. A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen. Dermatol Res Pract. 2024;8752787. DOI: https://doi.org/10.1155/2024/8752787

Vleminckx S, Virgilio N, Asserin J, Prawitt J, Silva CI. Influence of collagen peptide supplementation on visible signs of skin and nail health and‐aging in an East Asian population: A double blind, randomized, placebo‐controlled trial. J Cosmetic Dermatol. 2024;23(11):3645-53. DOI: https://doi.org/10.1111/jocd.16458