Bilateral malignant brenner tumour ovary; an extremely rare occurrence

Abstract

Malignant Brenner tumours (MBTs) are extremely rare ovarian neoplasms, constituting 1–5% of all Brenner tumours. They are typically found in women of the perimenopausal or postmenopausal age group of 50–70 years. MBT often manifest with nonspecific symptoms such as abdominal pain, abnormal uterine bleeding, and weight loss. Definitive diagnosis is possible on histologic examination only, as imaging features and serologic markers are non-specific and give inconsistent results. Being an extremely rare neoplasm, our knowledge about MBT is restricted to case series and case reports. Adding to the rarity, we report a bilateral MBT ovary in a 55-year-old perimenopausal woman presenting with the chief complaint of bilateral lower abdominal pain and discomfort. Ultrasonographic imaging revealed bilateral large adnexal masses of heterogeneous echogenicity, suggesting bilateral malignant ovarian tumour. CA125 was within the reference value. The patient then underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, and after the histopathologic examination diagnosis of bilateral MBT was made. Patient is on regular follow-up and was disease-free for 4 years until recently, when she developed pleural effusion and is under further investigation.