Formulation and evaluation of herbal periodontal films of M. paradisiaca for periodontitis
DOI:
https://doi.org/10.18203/2320-6012.ijrms20260245Keywords:
High density lipoprotein, Low density lipoprotein, Very low density lipoprotein, Hydroxy propyl methyl cellulose, Locally applied antimicrobial agentsAbstract
Background: The present work aims to formulate and evaluate the herbal films of M. paradisiaca for periodontitis.
Methods: Dental films were formulated using the ethanolic extract of M. paradisiaca by maceration with different polymers like HPMC K4M, Carbopol P71P. The ethanolic extract of M. Paradisiaca was subjected for the pre-formulations studies like preliminary phytochemical screening and the results showed the presence of flavonoids, carbohydrates, tannins, alkaloids, glycosides etc.
Results: The films were prepared by using the solvent casting technique and the films were subjected for various evaluation studies like thickness, hardness, folding endurance, surface PH. Based on the physiochemical parameters the formulation F1 were considered to be the best.
Conclusions: The present study reveals that both formulated films showed satisfactory film parameters. From the present investigation it can be concluded that film formulation incorporating banana peel extract can be a potential novel drug dosage form for treatment of Periodontitis.
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References
Victor M. Periodontal film for the treatment of periodontal disease. J Pharmaceut Sci Res. 2019;11(7):2579-84.
Herrera D, Tonetti MS, Chapple I, Kebschull M, Papapanou PN, Sculean A, et al. Consensus Report of the 20th European Workshop on Periodontology: Contemporary and Emerging Technologies in Periodontal Diagnosis. J Clin Periodontol. 2025;52(29):4-33. DOI: https://doi.org/10.1111/jcpe.14152
Babu Kunche H, Gulzar Ahmed M, Charyulu Rompicharla N. Development and evaluation of in situ gels of moxifloxacin for the treatment of periodontitis. Indonesian J Pharmacy. 2012;23(3):10.
Pragati S, Ashok S, Kuldeep S. Recent advances in periodontal drug delivery systems. Int J Drug Delivery. 2009;1(1):10. DOI: https://doi.org/10.5138/ijdd.2009.0975.0215.01001
Kothapuvari PK, Rawat S, Kadimpati KK. Preparation Of Fast Dissolving Oral Films Of New Generation Anti Migraine Drugs by Solvent Casting Method. Int J Curr Res. 2016;8(05):30704-10.
Ahmed MG, Harish NM, Charyulu RN, Prabhu P. Formulation of chitosan-based ciprofloxacin and diclofenac film for periodontitis therapy. Trop J Pharmaceut Res. 2009;8(1):33-41. DOI: https://doi.org/10.4314/tjpr.v8i1.14710
Abdelmagyd HA, Shetty SR, Al-Ahmari MM. Herbal medicine as adjunct in periodontal therapies-A review of clinical trials in past decade. J Oral Biol Craniofacial Res. 2019;9(3):212-7. DOI: https://doi.org/10.1016/j.jobcr.2019.05.001
Bansal S, Rastogi S, Bajpai M. Mechanical, chemical and herbal aspects of periodontitis: a review. Int J Pharmaceut Sci Res. 2012;3(5):1260.
Behiry SI, Okla MK, Alamri SA, EL-Hefny M, Salem MZ, Alaraidh IA, et al. Antifungal and antibacterial activities of Musa paradisiaca L. peel extract: HPLC analysis of phenolic and flavonoid contents. Processes. 2019;7(4):215. DOI: https://doi.org/10.3390/pr7040215
Dhuldhwaj R, Rajender A, Andhare M. Banana Peel (Musa paradisicia): Can it be a revolutionary Change in Periodontal Therapy? A Review. Int J Scientific Res. 2016;5(7):357-9.
Saleem M, Saeed MT. Potential application of waste fruit peels (orange, yellow lemon and banana) as wide range natural antimicrobial agent. J King Saud University Sci. 2020;32(1):805-10. DOI: https://doi.org/10.1016/j.jksus.2019.02.013
Youssef MA, Eman AA, Abeir ME. Evaluation the bioactive compounds extracted from dried banana (Musa sp.) peels which obtained by different drying methods. Curr Sci Int. 2018;7(2):135-48.
Ighodaro OM. Evaluation study on Nigerian species of Musa paradisiaca peels. Researcher. 2012;4(8):17-20.
Ehiowemwenguan G, Emoghene AO, Inetianbor JE. Antibacterial and phytochemical analysis of Banana fruit peel. Iosr J Pharm. 2014;4(8):18-25. DOI: https://doi.org/10.9790/3013-0408018025
Samal HB, Das IJ, Patra CN, Murthy PN. Design and development of dental film containing Aloe vera for the treatment of human periodontal diseases. Asian J Pharmacy Technol. 2015;5(4):273-80. DOI: https://doi.org/10.5958/2231-5713.2015.00036.7
Aviral K, Prajapati SK, Ali A, Kumar VS. Formulation and evaluation of dental film for periodontitis. IRJP. 2012;3:143-8.
Patidar MK, Karjikar FA, Patel FA, Rathi SS, Thokal SB, Bhingare CL. Formulation and evaluation of mouth dissolving films of zolpidem tartrate by exploration on polymers combination. Int J Pharm. 2013;3(4):716-21.
Rani JL. Formulation and in vitro and in vivo evaluation of oral dispersable films of loronoxicam. Int J Sci Tec. 2014;24(1):1649-55.
Alagusundaram M, Chengaiah B, Ramkanth S, Parameswari SA, Chetty C, Dhachinamoorthi D. Formulation and evaluation of mucoadhesive buccal films of ranitidine. Int J Pharmtech Res. 2009;1(3):557-63.
Suryono VM, Hafiyyah OA, Rasti DN, Widowati CA, Khusna A. Banana Peel Extract as Adjuvant Therapy for Periodontitis: Histometrical and Morphometrical Analysis in Rattus norvegicus. Int J. 2018;6(2):15-20. DOI: https://doi.org/10.15640/ijmp.v6n2a3
Urmi JI, Alam M, Pathan MS. Preparation and evaluation of ornidazole periodontal films. Bangladesh Pharmaceut J. 2016;19(2):133-46. DOI: https://doi.org/10.3329/bpj.v19i2.29271