Association of false-positive quadruple test and adverse pregnancy outcomes

Sanchai Jenjittikul; Putthaporn Thongphanang

doi:10.18203/2320-6012.ijrms20254354

Authors

Sanchai Jenjittikul Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand
Putthaporn Thongphanang Department of Obstetrics and Gynecology, Rajavithi Hospital, Bangkok, Thailand

DOI:

https://doi.org/10.18203/2320-6012.ijrms20254354

Keywords:

Quadruple test, Adverse pregnancy outcome, Serum marker

Abstract

Background: Aim of the study was to assess the relationship between false-positive quadruple test results and adverse pregnancy outcomes.

Methods: This retrospective case-control study was analysed data from 600 pregnant women who underwent second-trimester screening. The study compared 100 women with false-positive results (high risk group) to 500 women with true-negative results (low risk group). Odds ratios (OR) and adjusted OR (aOR) for various adverse pregnancy outcomes were calculated and compared between the groups.

Results: In this study, from 600 pregnant women in 2 groups. Some associations between high-risk group and adverse pregnancy outcomes can be found. The adjusted odds of developing gestational hypertension were significantly higher in the false-positive group (aOR 2.36, 95% CI: 1.07-5.18). Similarly, the risk of having a newborn with a low birth weight was also higher in this group (aOR 2.77, 95% CI: 1.06-7.24). No significant differences were observed between two groups regarding the rates of preeclampsia, gestational diabetes, fetal growth restriction and preterm labor.

Conclusions: Women with a false-positive quadruple test result have an increased risk of developing gestational hypertension and delivering a low-birth-weight newborn.

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