Guillian Barre syndrome and hyper-immunoglobulin E syndromes: an unusual correlation

Authors

  • Ajay Emani Department of Neurology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Ramakant Yadav Department of Neurology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Midhun Mohan Department of Neurology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
  • Roopesh Singh Kirar Department of Neurology, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20260018

Keywords:

Hyper IgE syndrome, Guillian Barre syndrome, Autoimmune, Peripheral nervous system

Abstract

Hyper immunoglobulin E (IgE) syndrome (HIES), also known as Job's syndrome, is a rare primary immunodeficiency disorder characterized by elevated levels of serum IgE, recurrent skin and lung infections, and eczema. Guillain-Barré syndrome (GBS) is an acute autoimmune condition that affects the peripheral nervous system, leading to muscle weakness and paralysis. This case report presents a unique instance of a 24-year-old male diagnosed with both HIES and GBS, exploring the clinical presentations, diagnostic challenges, and treatment approach.

 

References

Johansson SG. The History of IgE: From discovery to 2010. Curr Allergy Asthma Rep. 2011;11:173-7. DOI: https://doi.org/10.1007/s11882-010-0174-3

Amin K. The role of mast cells in allergic inflammation. Respir Med. 2012;106:9-14. DOI: https://doi.org/10.1016/j.rmed.2011.09.007

Choi J, Rho JH, Kim BJ. Guillain-Barré syndrome associated with hyper-IgE-emia. Ann Clin Neurophysiol. 2017;19(2):148-50. DOI: https://doi.org/10.14253/acn.2017.19.2.148

Kimura A, Yoshino H, Yuasa T. Chronic inflammatory demyelinating polyneuropathy in a patient with hyper IgE emia. J Neurol Sci. 2005;231:89-93. DOI: https://doi.org/10.1016/j.jns.2004.12.012

Coutinho BM, Nascimento OJ, Freitas MR. Distal acquired demyelinating symmetric neuropathy in two patients with essential hyper-IgEmia. Arq Neuropsiquiatr. 2013;71:493-94. DOI: https://doi.org/10.1590/0004-282X20130069

Pate MB, Smith JK, Chi DS, Krishnaswamy G. Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective. Clin Mol Allergy. 2010;8:3. DOI: https://doi.org/10.1186/1476-7961-8-3

Walker ME, Hatfield JK, Brown MA. New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta. 2012;1822:57-65. DOI: https://doi.org/10.1016/j.bbadis.2011.02.009

He L, Zhang G, Liu W, Gao T, Sheikh KA. Anti-Ganglioside antibodies induce nodal and axonal injury via Fcγ receptor-mediated inflammation. J Neurosci. 2015;35:6770-85. DOI: https://doi.org/10.1523/JNEUROSCI.4926-14.2015

Mathey EK, Derfuss T, Storch MK, Williams KR, Hales K, Woolley DR, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury. J Exp Med. 2007;204:2363-72. DOI: https://doi.org/10.1084/jem.20071053

Dines KC, Powell HC. Mast cell interactions with the nervous system: relationship to mechanisms of disease. J Neuropathol Exp Neurol. 1997;56:627-40. DOI: https://doi.org/10.1097/00005072-199706000-00001

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Published

2026-01-13

How to Cite

Emani, A., Yadav, R., Mohan, M., & Kirar, R. S. (2026). Guillian Barre syndrome and hyper-immunoglobulin E syndromes: an unusual correlation. International Journal of Research in Medical Sciences. https://doi.org/10.18203/2320-6012.ijrms20260018

Issue

In Press

Section

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