24 Hours chronomics of ambulatory blood pressure and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift health care workers


  • B. Anjum Department of Biochemistry,
  • Narsingh Verma Department of Physiology, Lucknow, UP
  • Sandeep Tiwari Department of Surgery King George’s Medical University, Lucknow, UP
  • Abbas A Mahdi Department of Biochemistry, Lucknow, UP
  • Ranjana Singh Department of Biochemistry, Lucknow, UP
  • Qulsoom Naaz Department of Physiology, Lucknow, UP
  • Saumya Mishra Department of Physiology, Lucknow, UP
  • Prerna Singh Department of Physiology, Lucknow, UP
  • Suman Gautam Department of Biochemistry, Lucknow, UP
  • Shipra Bhardwaj Department of Biochemistry, Lucknow, UP




Circadian rhythm, Entrainment, Rotating night shift


Background: Night shift workers have altered circadian pattern of blood pressure/heart rate and hormones like melatonin and cortisol. Due to this variation, night shift worker suffers from various cardiovascular disorders and hormonal disturbances.

Methods: The Present study was aimed to investigate the effects of rotating night shift on 24 hours chronomics of BP/HR and its relation with 6-sulfatoxy melatonin levels. 62 healthy nursing professionals, aged 20-40 year, performing day and night shift duties were recruited. Each month scheduled to continuous 9 days night shift (12 hours in regular 9 nights, from 20:00 to 08:00); after 9 days night shift they perform remaining duties in day shift and 4 days off in each month.

Results: Ambulatory BP and HR were recorded at every 30 min intervals in day time and each hour in night time synchronically with circadian pattern of 6 sulfatoxy melatonin during shift duties. Highly Significant difference was found in double amplitude (2DA) of blood pressure between night and day shift (p<0.001). In night shift, hyperbaric index (HBI) of mean systolic blood pressure was found to be increased at 00-03 am (midnight) while during day shift, peak was found at 06-09 am. Peak melatonin was to be found in early morning as compared to mid night in both the shift.

Conclusions: The present study concluded that the desynchronization was appeared during night shift and entrainment of circadian rhythm in the day shift.



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How to Cite

Anjum, B., Verma, N., Tiwari, S., Mahdi, A. A., Singh, R., Naaz, Q., Mishra, S., Singh, P., Gautam, S., & Bhardwaj, S. (2017). 24 Hours chronomics of ambulatory blood pressure and its relation with circadian rhythm of 6-sulfatoxy melatonin in night shift health care workers. International Journal of Research in Medical Sciences, 3(8), 1922–1931. https://doi.org/10.18203/2320-6012.ijrms20150302



Original Research Articles