Forty-eight-hour mortality in the emergency department: a record-based analysis of patterns and causes from a South Indian tertiary care centre
DOI:
https://doi.org/10.18203/2320-6012.ijrms20262609Keywords:
Prehospital referral, 48-hour mortality, Emergency department mortality, Medico-legal cases, Resuscitation failureAbstract
Background: Early mortality within 48 hours of emergency department (ED) admission is a key indicator of acute care quality. Limited Indian data exist on its epidemiology, especially regarding contributory factors in both medico-legal (MLC) and non-medico-legal (non-MLC) deaths. To determine the 48-hour mortality rate in the ED, describe demographic and clinical profiles, identify the duration of ED stay prior to death, and evaluate causes and contributing factors to early mortality.
Methods: This retrospective record-based study was conducted at a tertiary care center in South India over two years (January 2019–January 2021). All 132 patients who died within 48 hours of ED admission were included. Demographic and clinical parameters, cause of death, referral-to-death interval, and contributory factors (organizational, disease-related, human error) were analyzed descriptively and comparatively across MLC and non-MLC cases.
Results: Out of 96,560 emergency department visits, 132 patients died within 48 hours of ED arrival, corresponding to a mortality rate of 1.37 per 1,000 ED visits. Most patients (58%) died within 6 hours of admission. Cardiac causes (51.5%) and sepsis (26.8%) were predominant in non-MLC deaths, while trauma (60%) was the leading cause in MLC. Over 60% of patients died within 1–6 hours of referral from other centers. Disease-related causes accounted for 65.7% of MLC and 41.2% of non-MLC deaths, followed by organizational delays and human errors.
Conclusion: Early ED mortality is driven by both clinical severity and systemic delays. Stratified analysis of MLC and non-MLC cases reveals opportunities to strengthen prehospital referral systems, triage protocols, and resource allocation in emergency care.
References
Sweeny AL, Alsaba N, Grealish L, Denny K, Lukin B, Broadbent A, et al. The epidemiology of dying within 48 hours of presentation to emergency departments: a retrospective cohort study of older people across Australia and New Zealand. Age Ageing. 2024;53(4):67.
Jain A, Sase NN, Mathew AR, Paul IJ, Abhilash KPP, Ganesan P. Last breath in the emergency department. J Emerg Trauma Shock. 2019;12(4):263–7.
Kaeley N, Kumar J, Kumar M, Vempalli N, Dhar M, Bhardwaj BB, et al. Prevalence and pattern of geriatric emergencies in a teaching hospital of North India. J Fam Med Prim Care. 2021;10(10):3899–903.
Urs G, Zadey S, Kumar PK, Gangane T, Nimkar P, Staton C, et al. Emergency care in India: a retrospective cross-sectional analysis of health management and information system and global burden of disease. Emerg Med. 2024;8:2130.
Bhandarkar P, Patil P, Soni KD, O’Reilly GM, Dharap S, Mathew J, et al. An analysis of 30-day in-hospital trauma mortality in four urban university hospitals using the Australia India Trauma Registry. World J Surg. 2021;45(2):380–9.
Roy N, Gerdin M, Ghosh S, Gupta A, Kumar V, Khajanchi M, et al. 30-day in-hospital trauma mortality in four urban university hospitals using an Indian trauma registry. World J Surg. 2016;40(6):1299–307.
Sarang B, Bhandarkar P, Raykar N, O’Reilly GM, Soni KD, Wärnberg MG, et al. Associations of on-arrival vital signs with 24-hour in-hospital mortality in adult trauma patients admitted to four public university hospitals in urban India: a prospective multi-centre cohort study. Injury. 2021;52(5):1158–63.
Todi S, Mehta Y, Zirpe K, Dixit S, Kulkarni AP, Gurav S, et al. A multicentre prospective registry of one thousand sepsis patients admitted in Indian ICUs: (SEPSIS INDIA) study. Crit Care. 2024;28(1):375.
Bharati U, Regmi U. Prevalence and pattern of medico-legal cases in emergency department of a tertiary care centre in Kathmandu, Nepal. Nepal Med Coll J. 2023;25(3):230–5.
Abhilash KPP, Chakraborthy N, Pandian GR, Dhanawade VS, Bhanu TK, Priya K. Profile of trauma patients in the emergency department of a tertiary care hospital in South India. J Fam Med Prim Care. 2016;5(3):558–63.
Adhikari DD, Florence B, David SS. Prehospital trauma care in South India: a glance through the last 15 years. J Fam Med Prim Care. 2016;5(1):195–6.
Tekin FC, Köylü R, Köylü Ö, Kunt M. Factors related to resuscitation success and prognosis of cardiopulmonary arrest cases. Indian J Crit Care Med. 2023;27(1):26–31.
Rahim Khan U, Baig N, Bhojwani KM, Raheem A, Khan R, Ilyas A, et al. Epidemiology and outcomes of out of hospital cardiac arrest in Karachi, Pakistan – a longitudinal study. Resusc Plus. 2024;20:100773.
Khaleghi P, Akbari H, Masoudi Alavi N, Motalebi Kashani M, Batooli Z. Identification and analysis of human errors in emergency department nurses using SHERPA method. Int Emerg Nurs. 2022;62:101159.