Contralateral obstructive uropathy unveils eosinophilic solid and cystic renal cell carcinoma: a typical yet rare entity with rare presentation
DOI:
https://doi.org/10.18203/2320-6012.ijrms20260988Keywords:
Eosinophilic solid and cystic renal cell carcinoma, ESC-RCC, TSC, Obstructive uropathy, Subcapsular haemorrhageAbstract
The World Health Organization (WHO) 2022 kidney tumour classification has introduced a novel and uncommon type of renal cell carcinoma (RCC) known as eosinophilic solid and cystic renal cell carcinoma (ESC-RCC). ESCRCC is an under‑recognized, emerging new entity of sporadic renal neoplasms, with an approximate incidence of 0.2% of renal tumours. Approximately 70 cases have been reported in the literature till date. ESCRCC are usually seen in adult females, with a low stage and indolent behaviour, and rare incidence of recurrence or metastasis. They typically have solid and cystic morphology with very characteristic microscopy of abundant eosinophilic cytoplasm and prominent basophilic granules. They consistently harbor TSC1 or TSC2 mutations in tumour which is a proposed molecular marker for this entity. We presented hereby a case study in 56-year female with symptoms of contralateral obstructive uropathy for which patient underwent radiology and found out this tumour in opposite kidney. Uncommon gross presentation of extensive subcapsular haemorrhage and advanced TNM stage was noted in our case.
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Schreiner A, Daneshmand S, Bayne A, Countryman G, Corless CL, Troxell ML. Distinctive morphology of renal cell carcinomas in tuberous sclerosis. Int J Surg Pathol. 2010;18:409‑18. DOI: https://doi.org/10.1177/1066896909333510
Trpkov K, Hes O, Bonert M, Lopez JI, Bonsib SM, Nesi G, et al. Eosinophilic, solid, and cystic renal cell carcinoma clinicopathologic study of 16 unique, sporadic neoplasms occurring in women. Am J Surg Pathol. 2016;40:60‑71. DOI: https://doi.org/10.1097/PAS.0000000000000508
He X, Chen Y, Tang H, Xu Y, Zhu X, Wang C, et al. Eosinophilic Solid and Cystic Renal Cell Carcinoma with TSC2 mutation: a case report and literature review. Diagn Pathol. 2023;18(1):53. DOI: https://doi.org/10.1186/s13000-023-01341-9
Wang L, Jiang J. Eosinophilic Solid and Cystic Renal Cell Carcinoma: A New Entity. Asian J Surg. 2021; 44(10):1334-5. DOI: https://doi.org/10.1016/j.asjsur.2021.06.041
Mitha M, Ramamurthy S, Rajasekaran RB, Thippeswamy PB. Eosinophilic Solid and Cystic Renal Cell Carcinoma Presenting as Bone Metastasis: A Case Report and Literature Review. Ann Urol Oncol. 2025;8(3):122-6. DOI: https://doi.org/10.32948/auo.2025.11.28
Kidney Cancer. Statistics. Cancer. 2012.
Guo J, Tretiakova MS, Troxell ML, Osunkoya AO, Fadare O, Sangoi AR, et al. Tuberous sclerosis-associated renal cell carcinoma: a clinicopathologic study of 57 separate carcinomas in 18 patients. Am J Surg Pathol. 2014;38(11):1457-67. DOI: https://doi.org/10.1097/PAS.0000000000000248
Trpkov K, Hes O. New and emerging renal entities: a perspective post-WHO 2016 classification. Histopathology. 2019;74(1):31-59. DOI: https://doi.org/10.1111/his.13727
Trpkov K, Abou‑Ouf H, Hes O, Lopez JI, Nesi G, Comperat E, et al. Eosinophilic solid and cystic renal cell carcinoma (ESC RCC): further morphologic and molecular characterization of ESC RCC as a distinct entity. Am J Surg Pathol. 2017;41(10):1299-308. DOI: https://doi.org/10.1097/PAS.0000000000000838
Alomar K, Alia L, Qatleesh S, Mardenly F, Orabi A, Alhussein AA. A Rare Case of Eosinophilic Solid and Cystic Renal Cell Carcinoma in a 48-Year-OldWoman: Case Report and Literature Review. Int J Surg Case Rep. 2023;108:108463. DOI: https://doi.org/10.1016/j.ijscr.2023.108463
Parilla M, Kadri S, Patil SA, Ritterhouse L, Segal J, Henriksen KJ, et al. Are Sporadic Eosinophilic Solid and Cystic Renal Cell Carcinomas Characterized by Somatic Tuberous Sclerosis Gene Mutations?. Am J Surg Pathol. 2018;42(7):911-7. DOI: https://doi.org/10.1097/PAS.0000000000001067
Perrino CM, Grignon DJ, Williamson SR, Idrees MT, Eble JN, Cheng L. Morphological Spectrum of Renal Cell Carcinoma, Unclassified: An Analysis of 136 Cases. Histopathology. 2018;72(2):305-19. DOI: https://doi.org/10.1111/his.13362
Tretiakova MS. Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: Series of 4 primary tumors and 2 metastases. Hum Pathol. 2018;80:65‑75. DOI: https://doi.org/10.1016/j.humpath.2018.05.023
Loghin A, Popelea MC, Todea‑Moga CD, Cocuz IG, Borda A. Eosinophilic Solid and Cystic RenalCell Carcinoma—A Systematic Review and Meta-Analysis. Int J Mol Sci. 2024;25(11):5982. DOI: https://doi.org/10.3390/ijms25115982
Palsgrove DN, Li Y, Lin MT, Pallavajjalla A, Gocke C, De Marzo AM, et al. Eosinophilic solid and cystic (ESC) renal cell carcinomas harbor TSC mutations: Molecular analysis supports an expanding clinicopathologic spectrum. Am J Surg Pathol. 2018;42(9):1166‑81. DOI: https://doi.org/10.1097/PAS.0000000000001111
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