A comparative study of serum calcium, magnesium and its ratio in women of menopausal and reproductive age group


  • Seena Sukumaran Department of Physiology, Government Medical College, Manjeri, Malappuram, Kerala




Serum Ca2 , Serum Mg2 , Ca2 / Mg2 ratio, Women of reproductive age


Background: The menstrual cycle is the result of complex interacting processes within the hypothalamus, the hypophysis, the ovaries and the uterus. Patterns of change in plasma concentrations of various minerals have been the subject of several research endeavours. Therefore, the present study has been conducted to study and compare the serum calcium, magnesium and its ratio in menopausal and reproductive age group.

Methods: The study was performed in two groups of subjects with a control group of 30 healthy women of reproductive age group and a postmenopausal group of 30 women with varying durations of menopause (less than and more than 10 years after menopause). Three blood samples were obtained from the control group –one each in early follicular phase, ovulatory phase and during luteal phase for estimation of calcium and magnesium. One sample was taken from the menopausal age group for the estimation of calcium and magnesium using commercially available kit. The values are expressed as mean ± S.D. The comparison between the different phases of menstrual cycle in reproductive age group with menopausal women was performed using student t-test. P value less than 0.05 was considered significant.

Result: The serum Ca2+, Mg2+ and Calcium/ Magnesium ratiowas found to be statistically insignificant (p=1.00), during different phases of menstrual cycle in normal cycling women is statistically insignificant.

Discussion: The cyclical changes of serum Ca2+ and Serum Mg2+ levels in women of reproductive age may be due to the cyclical changes in the level of sex hormones during different phases of menstrual cycle.



Patricia M, Dolev E, Bernier LL. Magnesium and zinc status during menstrual cycle. Am J Obstet Gynaecol. 1987;157:964-8.

Ganong WF. Review of medical physiology 22nd edition. The gonads: development and function of the reproductive system. 433-447.

Ardlie NG, Nishiwaza EE, Guccione M. Effect of Ca++ and Mg++ on platelet function (abstr). Fed Proc. 1970;29:423.

Menon U, Burnell M, Sharma A, et al. Decline in use of hormone therapy among postmenopausal women in the United Kingdom. Menopause. 2007;14(3 Pt 1):462–7.

Muneyyirci-Delale O, Nacharaju VL, Dalloul M, Altura BM, Altura BT. Serum ionized magnesium and calcium in women after menopause: inverse relation of estrogen with ionized magnesium. Fertil Steril. 1999;71:869–72.

Pandya K, Martin HE, Mehl J, Wertman M. Clinical studies of magnesium metabolism. Med Clin N Am. 1952;36:1157-71.

Das K, Chowdhary AR. Metallic ions during menstrual cycle in normally menstruating women. Indian J med Sci. 1997;51:52-4,.

Seelig MS, Altura BM, Altura BT. Benefits anad risks of sex hormone replacement in postmenopausal women. Journal of American college of nutrition. 2004;23(5):482s – 96s.

Mauskop A, Altura BT, Cracco RQ. Intravenous magnesium sulphate relieves migraine attacks in patients with low aerum ionized magnesium levels. Clin Sci. 1995;89:633-6.

Freedman AM, Cassidy MM, Weglicki WB. Magnesium-deficient myocardium demonstrates an increased susceptibility to an in vivo oxidative stress. Magnes Res. 1991;4:185–9.




How to Cite

Sukumaran, S. (2017). A comparative study of serum calcium, magnesium and its ratio in women of menopausal and reproductive age group. International Journal of Research in Medical Sciences, 3(8), 2024–2028. https://doi.org/10.18203/2320-6012.ijrms20150320



Original Research Articles