Prevalence of Acinetobacter spp. in lower respiratory tract infections and its antimicrobial susceptibility pattern in a tertiary care hospital
DOI:
https://doi.org/10.18203/2320-6012.ijrms20261328Keywords:
Acinetobacter spp, Antimicrobial susceptibility pattern, Lower respiratory tract infections, Multidrug resistanceAbstract
Background: Acinetobacter spp. are regarded as commensal microbes of human skin and respiratory tract; however, they may cause serious infections, such as endocarditis, urinary tract infections (UTI), pneumonia, wound infections, especially in individuals with impaired host defenses. This study aimed to determine the prevalence and antimicrobial susceptibility pattern of Acinetobacter spp. isolated from lower respiratory tract (LRT) specimens in a tertiary care hospital in Jaipur, Rajasthan, India.
Methods: A total of 1031 lower respiratory tract (LRT) samples, including sputum, bronchoalveolar lavage (BAL), endotracheal tube (ET)/ aspirate and pleural fluid, were collected from inpatients and outpatients. Acinetobacter spp. were isolated and identified using standard microbiological techniques and antimicrobial susceptibility testing was performed.
Results: Out of 801 (77.69%) culture-positive samples, 136 (16.98%) were identified as Acinetobacter spp. The highest isolation rate was observed in ET samples (80.15%), followed by sputum (16.91%), BAL (2.21%) and pleural fluid (0.74%). The majority of Acinetobacter spp. were isolated from patients in the medical ICU (29.37%) and the critical care unit (26.98%). Antimicrobial susceptibility testing revealed high resistance rates to cefotaxime (99.26%), ceftriaxone (97.79%) and other antibiotics. Colistin was the only antibiotic to which all isolates were susceptible.
Conclusions: The high prevalence of multidrug-resistant Acinetobacter spp. in LRT infections poses a significant challenge for clinicians. Implementing strict infection control measures, judicious use of antibiotics and regular monitoring of antimicrobial susceptibility patterns are essential to prevent the spread of these resistant pathogens in healthcare settings.
References
Madhavi RB, Anitha D, Beena PM. Clinical and Antimicrobial profile of Acinetobacter Species at a Tertiary Care Teaching Hospital. J Pure Appl Microbiol. 2022;16(3):2066-71.
Saha S, Devi KM, Damrolien S. A study of Acinetobacter infections in a tertiary care hospital in Northeast India. Int J Res Med Sci. 2018;6(6):2076–80.
Rani C, Sharma SR, Farooq U, Singh S, Sharma V, Ahamad I. Isolation of Acinetobacter spp. and its antimicrobial resistance pattern in all lower respiratory samples from ICU. IP Int J Med Microbiol Trop Dis. 2022;8(2):118-22.
Jain M, Sharma A, Sen MK, Rani V, Gaind R, Suri JC. Phenotypic and molecular characterization of Acinetobacter baumannii isolates causing lower respiratory infections among ICU patients. Microb Pathog. 2019;128:75-81.
Gupta N, Gandham N, Jadhav S, Mishra RN. Isolation and identification of Acinetobacter species with special reference to antibiotic resistance. J Nat Sci Biol Med. 2015;6(1):159-62.
Thomas B, Sukumaran P, Seema, Midhun M, George D. Antimicrobial resistance of acinetobacter baumannii infection of lower respiratory tract and mortality – A cross-sectional study from a tertiary care teaching hospital in Kerala. IP Indian J Immunol Respir Med. 2018;3(4):183-7.
CLSI. Performance Standards for Antimicrobial Susceptibility Testing. 33rd ed. CLSI supplement M100. Clinical and Laboratory Standards Institute. 2023.
Wisplinghoff H, Perbix W, Seifert H. Risk factors for nosocomial bloodstream infections due to Acinetobacter baumannii: a case-control study of adult burn patients. Clinical infectious diseases. Publ Infect Dis Soc America. 1999;28(1):59–66.
Ayenew Z, Tigabu E, Syoum E, Ebrahim S, Assefa D, Tsige E. Multidrug resistance pattern of Acinetobacter species isolated from clinical specimens referred to the Ethiopian Public Health Institute: 2014 to 2018 trend anaylsis. PLoS ONE. 2021;16(4):250896.
Amber P. Antibiotic susceptibility pattern of Acinetobacter spp isolated from ICU at tertiary care hospital. 2018: 273-76.
Jayashree S, Rajeshwari KG, Wadekar MD. Drug Resistance Mechanism among Acinetobacter Species. J Pure Appl Microbiol. 2021;15(2):883-90.
Guddeti PK, Shah H, Karicheri R, Singh L. Clinical Profile of Patients and Antibiogram of Acinetobacter baumannii Isolates in a Tertiary Care Hospital, Central India. J Pure Appl Microbiol. 2023;17(3):1435-43.
Trilokhya P, Pavani G, Yazhini K, Manick Dass S. Risk Profile and Antimicrobial Susceptibility Pattern of Acinetobacter Baumannii Clinical Isolates in A Teaching Hospital in Hyderabad. Int J Adv Res. 2023;11:719-26.
Rajkumari S, Pradhan S, Sharma D. Prevalence and antibiogram of Acinetobacter species isolated from various clinical samples in a tertiary care hospital. J College Medical Sci-Nepal. 2020;16(1):26-32.
Sohail M, Rashid A, Aslam B, et al. Antimicrobial susceptibility of Acinetobacter clinical isolates and emerging antibiogram trends for nosocomial infection management. Revista da Sociedade Brasileira de Medicina Tropical. 2016;49(3):300–4.
Jabeen F, Khan Z, Sohail M, Tahir A, Tipu I, Saleem HGM. Antibiotic resistance pattern of Acinetobacter Baumannii isolated from bacteremia patients in Pakistan. J Ayub Med Coll Abbottabad. 2022;34(1):95–100.
Yadav MV. Isolation and speciation of Acinetobacter species with special reference to antibiotic Resistance in Tertiary Care Hospital. Int J Life Sci Pharma Res. 2023;13(4):76-87.
Peymani A, Nahaei MR, Farajnia S. High prevalence of metallo-beta-lactamase-producing Acinetobacter baumannii in a teaching hospital in Tabriz, Iran. Japan J Infect Dis. 2011;64(1):69–71.
Dimple R, Nupur S, Mahawal BS, Ankit K, Ajay P. Speciation and antibiotic resistance pattern of Acinetobacter species in a tertiary care hospital in Uttarakhand. International J Med Res Health Sci. 2016;5(4):89-96.
Prasad A, P Versha. Antibiotic susceptibility pattern of acinetobacter spp isolated from ICU at tertiary care hospital. 2018: 273-76.
Zabada AA, Saghirb SA, Al-Madhagic AK, Al-Moyedc KA. Acinetobacter baumannii complex and its antibiotics susceptibility in selected hospital's intensive care units at Sana’a city-Yemen. Glob Adv Res J Microbiol. 2018;7:047-56.
Tewari R, Chopra D, Wazahat R, Dhingra S, Dudeja M. Antimicrobial susceptibility patterns of an emerging multidrug resistant nosocomial pathogen: Acinetobacter baumannii. Malays J Med Sci. 2018;25(3):129–34.
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