DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20150326

To study the hypotensive and hypolipidemic effects of garlic in smokers in the North Indian population

Jayballabh Kumar, Gaurav Kumar, Farhan Ahmad Khan

Abstract


Background: Garlic, latin name Allium Sativum, belongs to the onion family Alliaceae, have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases like atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes.

Methods: This prospective study conducted on male smokers (n=40) in the department of physiology of Teerthanker Mahaveer Medical College & Research Centre. Selected smokers were further evaluated before and after giving raw fresh garlic weighing about 5-6gm daily for a month.

Sample 1:- Before taking garlic parameters.

Sample 2:- After taking garlic parameters.

After one month all the parameters were analyzed and compared with the baseline parameters.

Results: Garlic has a significant hypotensive effect by lowering DBP, SBP also lowered but it was not statistically significant. Also hypolipidemic effects of garlic were found to be statically significant in cases of triglyceride, HDL & LDL, but changes in cases of cholesterol and VLDL are not statically significant.

Conclusions: Garlic being hypotensive and hypolipidemic in nature as shown in our study, therefore it can be concluded that garlic is beneficial for human beings. Its main beneficial effect for decreasing the lipid levels as well as the blood pressure in smokers.


Keywords


Garlic, Lipid parameters, Hypolipidemic agents, Smokers

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References


Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders; a review. Nutr J. 2002;1:4.

Omvik P. How smoking affects blood pressure. Blood Press. 1996;5(2):71-7.

Ghannem H, Harrabi I, Ben AA, Gaha R, Trabelsi L. Smoking habits and cardiovascular risk factors among adolescents in Sousse, Tunisia. Arch Public Health. 2003;61:151-60.

Wynder EL, Harris RE, Haley NJ. Population screening for plasma cholesterol. Community based results from Connecticut. Am Heart J. 1989;117:649-56.

Mammas IO, Bertsias GK, Linardakis M, Tzanakis NE, Lapidaries DN, Kafatos AG. Cigarette smoking, alcohol consumption, and serum lipid profile among medical students in Greece. European Journal of Public Health. 2003;13:278–82.

Neki NS. Lipid profile in chronic smokers-A clinical Study. JIACM. 2002;3(1):51-4.

Yasue H, Hirai N, Mizuno Y, Harada E, Itoh T, Yoshimura M, et al. Low grade inflammation, thrombogenicity, and atherogenic lipid profile in cigarette smokers. Circ J. 2006;70(1):8-13.

Guedes DP, Guedes JE, Barbosa DS, de Oliveira JA. Tobacco use and plasma lipid –lipoprotein profile in adolescents. Rev Assoc Med Bras. 2007;53(1):59-63.

Wakabayashi I. Associations of alcohol drinking and cigarette smoking with serum lipid levels in healthy middle-aged men. Alcohol Alcohol. 2008;43(3):274-80.

Shai I, Rimm EB, Hankinson SE, Curhan G, Manson JE, Rifai N, et al. . Multivariate assessment of lipid parameters as predictors of coronary heart disease among postmenopausal women: potential implications for clinical guidelines. Circulation. 2004;110(18):2824-30.

Wei W, Kim Y, Boudreau N. Association of Smoking with Serum and Dietary Levels of Antioxidants in Adults: HANES III, 1988–1994. Am J Public Health. 2001;91(2):258-64.

Mezzetti A, Lapenna D, Pierdomenico SD, Calafiore AM , Costantini F, Riario-sforza G, et al. Vitamins E ,C And lipid peroxidation in plasma and arterial tissue of smokers and non-smokers. Atherosclerosis. 1995;112(1):91-9.

Zeiher AM, Schachinger V, Minners J. Long term cigarette smoking impairs endothelial dependent coronary artery vasodilator function. Circulation. 1995;92(5):1094-100.

Rahman K. Historical perspective on garlic and cardiovascular disease. J Nutr. 2001;131(3s):977S-9S.

Bordia A, Bansal HC. Letter: Essential oil of garlic in prevention of atherosclerosis. Lancet. 1973;2(7844):1491-2.

Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb Res. 1983;32(2):155-69.

Tang Z1, Sheng Z, Liu S, Jian X, Sun K, Yan M. The preventing function of garlic on experimental oral precancer and its effect on natural killer cells, T-lymphocytes and interleukin-2. Hunan Yi Ke Da Xue Xue Bao. 1997;22(3):246-8.

Leoper M, DeBray M. Hypotensive effect of tincture of garlic. Prog Med. 1921;36:391–2.

Petkov V. Plants and hypotensive, antiatheromatous and coronarodilatating action. Am J Chin Med. 1979;7(3):197-236.

Kharb S, Singh GP. Effect of smoking on lipid profile, lipid per oxidation and antioxidant status in patient during and after acute myocardial infarction. Clinic Chemical. 2000;302:213-219.