Vitamin D3 status in pre-menopausal and post-menopausal type 2 diabetes mellitus women

Jessica Maurya; Naina Singh; Hemlata Rathore; Uma Gupta; Brijesh Rathore

doi:10.18203/2320-6012.ijrms20260967

Authors

Jessica Maurya M.Sc. Medical Biochemistry Scholar, Era University, Sarfarajganj, Hardoi Road, Lucknow, Uttar Pradesh, India
Naina Singh M.Sc. Medical Biochemistry Scholar, Era University, Sarfarajganj, Hardoi Road, Lucknow, Uttar Pradesh, India
Hemlata Rathore Department of Physiology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India
Uma Gupta Department of Obstetrics and Gynecology, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India
Brijesh Rathore Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20260967

Keywords:

Post-menopausal, Pre-menopausal, Type 2 diabetes mellitus, Vitamin D3

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic condition that arises from either total or partial deficiency of insulin. It is a multifactorial disorder characterised by abnormal glucose metabolism, persistent high blood glucose levels, and altered insulin release. Recent study suggest that vitamin D may play a protective role against malignancies, cardiovascular conditions, diabetes, osteoporosis, and various other bone-related diseases. Numerous studies have highlighted a high prevalence of vitamin D deficiency among postmenopausal women, with some suggesting an association with diabetes and metabolic syndrome. Therefore, we aim to assess serum vitamin D₃ status in T2DM pre-menopausal and post-menopausal women.

Methods: We conducted a cross-sectional study with 104 T2DM pre-menopausal and 104 T2DM post-menopausal women visiting the OPD of Obstetrics and Gynecology. Study population age ranging between 25 to 70 years were recruited and biochemical analysis was done.

Results: Mean age (mean±SD) of pre-menopausal and post-menopausal women was recorded as 33.03±5.89 years, and 57.23±8.72 years, respectively. Fasting blood glucose levels in pre-menopausal and post-menopausal women were 199.89±61.69 and 195.09±68.85, respectively, similarly HbA1c values in pre-menopausal and post-menopausal women were 8.70±2.01 and 8.63±2.23, respectively. Serum vitamin D₃ levels (mean±SD) were recorded as 43.64±17.91 and 37.08±16.26 in pre-menopausal and post-menopausal women, respectively. A statistically significant (p<0.002) decrease in serum vitamin D₃ level was found in post-menopausal women as compared to pre-menopausal women.

Conclusions: Results of our study shows statistically significant decrease in serum vitamin D₃ levels in post-menopausal T2DM women as compared to pre-menopausal T2DM women.

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