Comparison of clinical profile and in hospital outcome of acute kidney injury in diabetic and non-diabetic hospitalized patients in tertiary care hospital: a prospective observational analytical study
DOI:
https://doi.org/10.18203/2320-6012.ijrms20261684Keywords:
Acute kidney injury, Chronic kidney disease, Type 2 diabetes mellitus, Renal replacement therapyAbstract
Background: Diabetic and non-diabetic patients experience AKI of variable severity. Not much data exists about the comparison between these two with follow-up of the renal recovery. We here describe this study for bridging the knowledge gap.
Methods: Diabetic and non-diabetic patients having AKI were identified during the study period (n=66 each) at AIIMS Rishikesh in prospective manner. Patients were followed up and results were compared till the period of hospitalization.
Results: In Demographics, Diabetic patients were more in middle age (p-value-<0.001). diabetic patients had more underlying CKD than non-diabetic (p value-<0.001). severity of AKI, RRT requirement and outcomes were comparable in both groups. Out of 132, only 4 patients (3 diabetics and 1 non-diabetic) had mortality. Overall, AKI and its outcomes and mortality are comparable in diabetic and non-diabetic patients.
Conclusions: Primary objective being the in-hospital mortality rates is comparable between two groups and so is the need of renal replacement therapy and renal recovery at discharge. Most of the diabetic patients experiencing AKI episodes were in middle age to elder group, while non-diabetics have more of young and middle age predominance difference between them were statistically significant. In terms of AKI episodes, difference of prevalence of CKD and hypertension was more in diabetic group (p value <0.001).
References
Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet. 2012;380(9843):756-66.
Al-Jaghbeer M, Dealmeida D, Bilderback A, Ambrosino R, Kellum JA. Clinical decision support for in-hospital AKI. J Am Soc Nephrol. 2018;29(2):654-60.
Hapca S, Siddiqui MK, Kwan RS, Guzik TJ, Byrne JM, Sattar N, et al. BEAt-DKD Consortium. The relationship between AKI and CKD in patients with type 2 diabetes: an observational cohort study. J Am Soc Nephrol. 2021;32(1):138-50.
Alicic RZ, Rooney MT, Tuttle KR. Diabetic kidney disease: challenges, progress, and possibilities. Clin j Am Soc Nephrol. 2017;12(12):2032-45.
Yu SM, Bonventre JV. Acute kidney injury and progression of diabetic kidney disease. Adv chronic kidney dis. 2018;25(2):166-80.
Peng J, Li X, Zhang D, Zhang J, Liu L, Xu W, et al. Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury. Kidney Int. 2015;87(1):137-50.
Team NG. Acute kidney injury: prevention, detection and management. National Institute for Health and Care Excellence (UK). 2019. Available at: https://www.nice.org.uk/guidance/ng148. Accessed on 26 January 2026.
Saxena A, Meshram S. Predictors of mortality in acute kidney injury patients admitted to medicine intensive care unit in a Rural Tertiary Care Hospital. Indian J Crit Care Med. 2018;22(4):231-7.
Prabhu RA, Shenoy SV, Nagaraju SP, Rangaswamy D, Rao IR, Bhojaraja MV, et al. Acute kidney injury and progressive diabetic kidney disease: An epidemiological perspective. Int J Nephrol Renovasc Dis. 2021;14:23-31.
Johnson F, Phillips D, Talabani B, Wonnacott A, Meran S, Phillips AO. The impact of acute kidney injury in diabetes mellitus. Nephrol. 2016;21(6):506-11.
Sohaney R, Yin H, Shahinian V, Saran R, Burrows NR, Pavkov ME, et al. In-hospital and 1-year mortality trends in a national cohort of US veterans with acute kidney injury. Clin J Am Soc Nephrol. 2022;17(2):184-93.
Downloads
Published
How to Cite
Issue
Section
