Autologous serum as an alternative to fibrin glue for conjunctival autograft fixation in sutureless pterygium surgery

Jannatul Ferdause; Mohammad Abdul Kadir; Rifat Hasan; Farhana Munmun; Sourav Das; Umma Asma Saki; Anamul Haque; Trishna Saha

doi:10.18203/2320-6012.ijrms20261327

Authors

Jannatul Ferdause Department of Ophthalmology, Mugda Medical College Hospital, Dhaka, Bangladesh
Mohammad Abdul Kadir Department of Medicine, Mugda Medical College Hospital, Dhaka, Bangladesh
Rifat Hasan Department of Transfusion Medicine, National Institute of Burn and Plastic Surgery, Dhaka, Bangladesh
Farhana Munmun Department of Transfusion Medicine, Green Life Hospital, Dhaka, Bangladesh
Sourav Das Department of Transfusion Medicine, National Centre for Control of Rheumatic Fever and Heart Diseases, Dhaka, Bangladesh
Umma Asma Saki Department of Transfusion Medicine, KPJ Specialized Hospital, Dhaka, Bangladesh
Anamul Haque Department of Medicine, Mugda Medical College Hospital, Dhaka, Bangladesh
Trishna Saha Department of Transfusion Medicine, National Institute of Kidney Diseases and Urology, Sher-E-Bangla Nagar, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-6012.ijrms20261327

Keywords:

Pterygium, Autologous serum, Fibrin glue, Conjunctival autograft, Recurrence

Abstract

Background: Pterygium is a common ultraviolet (UV)-related ocular surface disorder. Although conjunctival autografting lowers recurrence, the optimal graft fixation method remains debated. Autologous serum offers a cost-effective alternative to fibrin glue in sutureless pterygium surgery. Objectives were to compare the efficacy of autologous serum and fibrin glue for conjunctival autograft fixation in sutureless pterygium surgery.

Methods: This prospective randomized comparative interventional study was conducted at the Department of Ophthalmology, Dhaka Medical College Hospital, from January to July 2020. Sixty patients with primary nasal pterygium were randomly allocated into two groups: Group A (autologous serum) and group B (fibrin glue), with 30 patients in each group. Operative time, graft adherence, postoperative symptoms, complications, and recurrence at 3 months were evaluated. Data were analyzed using SPSS version 22, and p<0.05 was considered statistically significant.

Results: The mean surgical time was 23.11±1.69 minutes in group A and 24.41±1.19 minutes in group B (p=0.084). Complete graft adherence on the first postoperative day was observed in 96.7% of group A and 100% of group B. Postoperative symptoms were present in 50.0% and 60.0% of patients, respectively (p=0.463). Recurrence at 3 months occurred in 3.3% of group A and none in group B (p=1.000). No statistically significant differences were found between groups.

Conclusions: Autologous serum is a safe, effective, and economical alternative to fibrin glue for conjunctival autograft fixation in sutureless pterygium surgery.

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