The role of Rouvière’s sulcus and R4U line in safe laparoscopic cholecystectomy: a prospective observational study of 130 cases
DOI:
https://doi.org/10.18203/2320-6012.ijrms20261685Keywords:
Subtotal cholecystectomy, Liver function test, USG, Critical view of safety, Rouvière’s sulcus, R4U line, Laparoscopic cholecystectomy, Bile duct injuryAbstract
Background: Bile duct injury (BDI) remains a serious complication of laparoscopic cholecystectomy (LC), most commonly due to misinterpretation of biliary anatomy. Rouvière’s sulcus (RVS) is an extra-biliary anatomical landmark that defines the plane of the common bile duct, while the R4U line delineates a safe zone for dissection. Identification of these landmarks may reduce the risk of BDI, particularly in difficult cholecystectomies.
Methods: This prospective observational study was conducted at a tertiary care center between March 2023 and March 2025. A total of 130 patients undergoing elective LC for symptomatic gallstone disease was included. RVS was identified intraoperatively and classified according to presence, type, orientation, and dimensions. In cases where RVS was absent, dissection was guided by the R4U line. Operative difficulty was graded using the modified Nassar scale. Outcomes assessed included achievement of the critical view of safety (CVS), bile duct injury, bile leak, conversion to open surgery, and need for subtotal cholecystectomy.
Results: Was identified in 106 patients (81.5%). The open type was the most common morphology (72.6%), with a predominantly horizontal orientation. CVS was achieved in all cases. No bile duct injuries were recorded. Bile leakage occurred only in patients undergoing subtotal cholecystectomy. Conversion to open surgery was required only in early cases of the study. With increasing adherence to RVS and R4U-guided dissection, difficult cases were successfully managed laparoscopically.
Conclusions: Rouvière’s sulcus is a reliable and consistent anatomical landmark for safe laparoscopic cholecystectomy. When absent, the R4U line provides an effective alternative guide. Routine identification and use of these landmarks may significantly reduce the risk of bile duct injury.
References
Gans HO. The anatomy of the liver. Thesis. Amsterdam: University of Amsterdam. 1955.
Couinaud C. Le foie: études anatomiques et chirurgicales. Paris: Masson. 1957.
Reynaud Y, Couinaud C. Le sillon du processus caudé (sillon de Rouvière). Bull Assoc Anat (Nancy). 1953;38:243-6.
Lim KH, Rajan S, Choi SH, Park HJ. Rouvière’s sulcus: A useful landmark in laparoscopic cholecystectomy to prevent bile duct injury. World J Gastroenterol. 2020;26(48):7610-22.
Sivaraman A, Sadhasivam M, Shankar M, Chandramohan SM. Rouviere’s Sulcus: An additional guide for safe laparoscopic cholecystectomy. Int Surg J. 2017;4(6):1993-7.
Gandhi A, Majumder A, Bindal V, Gandhi S. Importance of Rouviere’s sulcus in laparoscopic cholecystectomy: A cross-sectional study. Int Surg J. 2019;6(5):1493-7.
Nassar AH, Ng HJ, Hamade AM. Safe cholecystectomy: the R4U line and Rouvière’s sulcus. Ann R Coll Surg Engl. 2020;102(2):139-42.
Sharma D, Khullar R, Soni V, Baijal M, Chowbey PK. Role of Rouviere’s Sulcus in safe laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2007;17(4):436-8.
Sasaki A, Nakajima J, Nitta H, Obuchi T, Baba S, Wakabayashi G. Identification of Rouvière’s sulcus as an anatomical landmark in laparoscopic cholecystectomy. Surg Endosc. 2007;21(9):1591-4.
Palanivelu C, Rangarajan M, Senthilkumar R, Parthasarathi R, Rajapandian S, Babu NR. Safe laparoscopic cholecystectomy: The importance of the R4U line. World J Surg. 2008;32(3):391-5.
Garg P, Thakur JD, Singla SL, Chandel N, Shekhawat NS. Rouviere’s sulcus: A valuable landmark in laparoscopic cholecystectomy. World J Gastrointest Surg. 2016;8(6):436-40.
Sundararajan LS, Muthukumar M, Sundaramurthi S, Rajamurugan A, Thirugnanam S, Kumaran V. The R4U line in safe laparoscopic cholecystectomy: a retrospective analysis. Int J Surg. 2021;93:106049.
Nasseri Y, Berber E. Rouviere’s sulcus: An important landmark for safe laparoscopic cholecystectomy. Surg Laparosc Endosc Percutan Tech. 2012;22(3):e122-4.
Singh P, Yadav R, Chauhan N. Role of Rouviere’s sulcus in safe laparoscopic cholecystectomy: a clinical study. Int J Contemp Med Res. 2018;5(2):B1-3.
Yokoe M, Hata J, Takada T. Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2018;25(1):41-54.