Correlation between histopathological variant and anatomical site of meningiomas: a single centre study
DOI:
https://doi.org/10.18203/2320-6012.ijrms20262177Keywords:
Meningioma, Histopathology, Anatomical site, WHO grading, Central nervous system tumoursAbstract
Background: Meningiomas are among the most common primary tumors of the central nervous system, arising from arachnoidal cap cells. They show diverse histopathological variants and occur at various sites within the craniospinal axis. Studying the correlation between histological subtype and tumor location may help in predicting tumor behavior, guiding surgical management and assessing prognosis.
Methods: A retrospective study was conducted over one year for a sample size of 51 histopathologically confirmed cases of meningioma. Clinical details, anatomical location, histopathological subtype and WHO grade were reviewed. Tumors were classified according to WHO 2021 criteria and the association between histological variants and anatomical sites was analysed.
Results: Of all the cases studied, 58.8% were females and 41.2% males, with the highest incidence in the 51–60 years age group (33.3%). The most common site was the parasagittal region (41.1%), followed by free convexity (19.6%) and spinal region (11.7%). Histologically, meningothelial meningioma was the most frequent subtype (60.7%), followed by fibroblastic (13.7%), transitional (5.88%) and psammomatous (5.88%) variants. WHO Grade I tumors accounted for 86.2% of cases, Grade II for 9.88% and Grade III for 3.92%. Higher-grade tumors demonstrated increased mitotic activity, hypercellularity, necrosis and brain infiltration. A significant correlation was observed between certain histological variants and anatomical sites, particularly meningothelial meningioma in the parasagittal region.
Conclusions: Meningiomas commonly occur in middle-aged females and are most frequently located in the parasagittal region. The meningothelial subtype and WHO Grade I tumors predominate. Correlation between histological subtype and tumor location provides useful insights for clinical management and prognosis.
References
Backer-Grøndahl T, Moen BH, Torp SH. The histopathological spectrum of human meningiomas. Int J Clin Exp Pathol. 2012;5(3):231-42.
Ogasawara C, Philbrick BD, Adamson DC. Meningioma: a review of epidemiology, pathology, diagnosis, treatment and future directions. Biomedicines. 2021;9(3):319.
Li J, Fang L, Killer HE, Flammer J, Meyer P, Neutzner A. Meningothelial cells as part of the central nervous system host defence. Biology of the Cell. 2013;105(7):304-15.
Bhat AR, Wani MA, Kirmani AR, Ramzan AU. Histological-subtypes and anatomical location correlated in meningeal brain tumors (meningiomas). J Neurosci Rural Pract. 2014;5(3):244-9.
Shrestha R, Bishokarma S, Shrestha S, Gurung S, Thapa ER, Rayamajhi S, et al. Spatial distribution of histological subtypes of Meningioma: A 14-Year longitudinal study in a developing country. Interdisciplinary Neurosur. 2024;36:101921.
Patel PJ, Trupti RJ, Chaudhari VV. Clinicopathological study of meningioma. Trop J Pathol Microbiol. 2019;6(1):9-17.
Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. “Epidemiology of intracranial meningioma.” Neurosurgery. 2005;57:1088-95.
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97-109.
Gadgil NM, Margam SR, Chaudhari CS, Kumavat PV. The histopathological spectrum of meningeal neoplasms. Indian J Pathol Oncol. 2016;3(3):432-6.
Louis DN, Scheithauer BW, Budka H, von Deimling A, Kepes JJ. “Meningeal tumours.” World Health Organization classification of tumours: pathology and genetics of tumours of the nervous system. IARC. 2000;11:176-84.
Lantos PL, Vandenberg SR, Kleihues P. “Tumours of the nervous system” in Graham DI, Lantos PL. Greenfield’s Neuropathology. 7th Edition, London: Arnold. 2002: 909-926.
Ng H-K, Tse CCH, Lo STH. “Microcystic meningiomas- an unusual morphological variant of meningiomas.” Histopatlology. 1989;14(1):1-9.
Alguacil-Garcia A, Pettigrew NM, Sima AA. Secretory meningioma. A distinct subtype of meningioma. Am J Surg Pathol. 1986;10(2):102-11.
Louis DN, Hamilton AJ, Sobel RA, Ojemann RG. Pseudopsammomatous meningioma with elevated serum carcinoembryonic antigen: a true secretory meningioma. Case report. J Neurosurg. 1991;74(1):129-32.
Maier H, Ofner D, Hittmair A, Kitz K, Budka H. “ Classic, atypical and anaplastic meningioma: three histopathological subtypes of clinical relevance.” J Neurosurg. 1992;77:616-23.
Avninder S, Vermani S, Shruti S, Chand K. Papillary meningioma: a rare but distinct variant of malignant meningioma. Diagn Pathol. 2007;19:33.
Perry A, Scheithauer BW, Stafford SL, Abell-Aleff PC, Meyer FB. “Rhabdoid meningioma- An aggressive variant.” Am J Surg Pathol. 1998;22:1482-90.
Kepes JJ, Moral LA, Wilkinson SB, Abdullah A, Llena JF. Rhabdoid transformation of tumor cells in meningiomas: a histologic indication of increased proliferative activity: report of four cases. Am J Surg Pathol. 1998;22(2):231-8.
Shenoy A, Khade S, Waghmare R. Meningioma: A clinicopathological correlation. Ann Pathol Lab Med. 2019;6(3):149-57.
Pant I, Chaturvedi S, Sarma P, Singh G. Histopathological mapping of meningiomas: a 10-year retrospective analysis. Indian J Neurosurg. 2021;10(03):203-9.
Soni N, Ora M, Bathla G, Szekeres D, Desai A, Pillai JJ, et al. Meningioma: molecular updates from the 2021 World Health Organization classification of CNS tumors and imaging correlates. American J Neuroradiol. 2025;1;46(2):240-50.
Downloads
Published
How to Cite
Issue
Section
