Electrocardiographic ventricular repolarization markers associated with obstructive coronary atherosclerosis in patients with coronary artery disease

Liudmila Kalatsei; Vimansa S. Liyanage; Chamodya H. Thathsarani

doi:10.18203/2320-6012.ijrms20261665

Authors

Liudmila Kalatsei Department of Internal Medicine 1, Grodno State Medical University, Grodno, Belarus
Vimansa S. Liyanage Department of Internal Medicine 1, Grodno State Medical University, Grodno, Belarus
Chamodya H. Thathsarani Department of Internal Medicine 1, Grodno State Medical University, Grodno, Belarus

DOI:

https://doi.org/10.18203/2320-6012.ijrms20261665

Keywords:

Atherosclerosis, Coronary artery disease, QT interval, Repolarization, Tpeak - Tend interval

Abstract

Background: In patients with coronary artery disease (CAD), myocardial ischemia is manifested by an increase in the instability of cardiomyocytes which is potentially characterized by QT interval and T_peak - T_end interval duration. This highlights the relevance of this study, which was aimed at the evaluation of electrocardiographic ventricular repolarization parameters associated with obstructive coronary atherosclerosis in patients with CAD.

Methods: The study included 63 patients with CAD and stable angina class I-III, referred for coronary angiography. 26 (41%) patients didn’t have hemodynamically significant CAD (stenosis <50%) (group 1), and 37 (59%) patients had significant CAD (stenosis ≥50%) (group 2). At admission, a resting standard 12-lead ECG was recorded, taken at a paper speed of 50 mm/sec. Statistical analysis was performed using the STATISTICA 12.0.

Results: Patients of both groups were comparable in age, prevalence of hypertension, obesity, diabetes mellitus, and atrial fibrillation (p>0.05). Patients of group 2 were predominantly male (p=0.04) and more often suffered from myocardial infarction (p=0.03) than patients of group 1. QT interval duration was greater in patients of group 2 compared with group 1 (p=0.049), as well as T_peak - T_end interval duration (p=0.019).

Conclusions: Patients with significant obstructive CAD had greater values of QT interval and T_peak - T_end interval (p<0.05) in comparison with patients without coronary atherosclerosis. These parameters may be further used as potential ECG predictors of CAD and assist in risk stratification before coronary angiography.

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