Association of serum uric acid in type II diabetes mellitus patients with and without diabetic retinopathy: a case control study

Ruchika Agarwal; Harnoor Jot; Pallavi Dhawan; Mili Jain; Sharwan; Sadaf Khan; Namrata

doi:10.18203/2320-6012.ijrms20262180

Authors

Ruchika Agarwal Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
Harnoor Jot Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
Pallavi Dhawan Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
Mili Jain Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India
Sharwan Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
Sadaf Khan Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India
Namrata Department of Ophthalmology, Rama Medical College Hospital and Research Centre, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20262180

Keywords:

Diabetic retinopathy, Uric acid, Hyperuricemia, Diabetic profile, Intraocular pressure

Abstract

Background: The objective of the study was to assess the association between serum uric acid levels and diabetic retinopathy.

Methods: An analytical case-control study was planned in which a total of 200 diabetic patients aged 40 to 65 years were enrolled divided into 2 groups, 100 diabetic patients with retinopathy and 100 diabetic patients without retinopathy. Both the groups of patients underwent complete ocular examination including assessment of best visual acuity, intraocular pressure, diabetic profile and uric acid assessment.

Results: Prevalence of hyperuricemia was 41% in cases as compared to 19% in controls, thus depicting a significant difference between two groups. Uric acid levels of mild and moderate NPDR cases were significantly lower than that of cases with severe/very severe non-proliferative diabetic retinopathy (NPDR) while proliferative diabetic retinopathy (PDR) cases had higher mean value as compared to all the NPDR types.

Conclusions: The findings of the study suggest that diabetic retinopathy is marked by an increase in uric acid levels and hyperuricemia.

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