The Pickwickian child: a case report of paediatric obesity hypoventilation syndrome

Authors

  • Aditi Dandawate Department of Paediatrics, Hinduhridaysamrat Medical College, Mumbai, Maharashtra, India
  • Norris Rodrigues Dr. Joshi Children’s Hospital, Mumbai, Maharashtra, India
  • Rayyan Sunasra Department of Paediatrics, Hinduhridaysamrat Medical College, Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20262205

Keywords:

Pediatric obesity, Obesity hypoventilation syndrome, Pediatric sleep

Abstract

Childhood obesity is on the rise and with it are also some unusual complications like Obesity hypoventilation syndrome, the triad of which includes obesity, hypoventilation and sleep disordered breathing. The absence of a mechanical, neuromuscular or metabolic explanation is essential before making this diagnosis. We report the case of a 10-year-old male child who was brought to us for the first time with acute onset breathlessness on exertion and generalised oedema, with progressive weight gain in the last 3 years. He was diagnosed with OHS with severe Obstructive sleep apnoea leading to cardiac failure and eventually improved with antifailure treatment, sildenafil, lifestyle modifications and BiPAP. Prompt recognition and early initiation of treatment measures including stringent lifestyle modifications are essential in preventing complications of OHS like cardiac failure.

References

Petrongari D, Di Filippo P, Cacciatore F, Di Ludovico A, Sferrazza Papa GF, Di Pillo S, et al. Obesity Hypoventilation Syndrome in Children and Adolescents. Children (Basel). 2026;13(1):140.

Mokhlesi B, Kryger MH, Grunstein RR. Assessment and management of patients with obesity hypoventilation syndrome. Proc Am Thorac Soc. 2008;5(2):218-25.

Fadl AA, Shahatah MA, Asiri AYS, Ogran MYS, Alyami ATT, Alasmari AM, et al. Overview on pediatric obesity hypoventilation syndrome. Saudi Med Horiz J. 2023;3(3):110-7.

Amorim MR, Aung O, Mokhlesi B, Polotsky VY. Leptin-mediated neural targets in obesity hypoventilation syndrome. Sleep. 2022;45(11):zsac153.

Branstiter GW, Lempert NL, Sotomayor T. Obesity hypoventilation syndrome in a 12-year-old child requiring therapeutic phlebotomy: case report and review of the literature. Pediatr Int. 2014;56(6):e99-101.

Goldbart AD, Greenberg-Dotan S, Tal A. Montelukast for children with obstructive sleep apnea: A double-blind, placebo-controlled study. Pediatrics. 2012;130(3):e575-80.

Gachelin E, Reynaud R, Dubus JC, Stremler-Le Bel N. Dépistage et prise en charge des anomalies respiratoires de L’Enfant obèse: Syndrome d’apnée obstructive du sommeil et syndrome d’obésité hypoventilation. Arch Pediatr. 2015;22(9):908-15.

Isaac B, Alexander C, John R, Kumar A, Singh P, Rao M, et al. Prevalence and predictors of obesity hypoventilation syndrome in an Indian cohort with obstructive sleep apnea. Sci Rep. 2025;15:23474.

Downloads

Published

2026-06-29

How to Cite

Dandawate, A., Rodrigues, N., & Sunasra, R. (2026). The Pickwickian child: a case report of paediatric obesity hypoventilation syndrome. International Journal of Research in Medical Sciences, 14(7), 3100–3103. https://doi.org/10.18203/2320-6012.ijrms20262205

Issue

Section

Case Reports