First dual-chamber leadless pacemaker implantation at Meitra United Heart Centre, Kasaragod: a regional milestone in an octogenarian with sick sinus syndrome: a case report

Authors

  • Bharathesh U. G. Department of Cardiology, Meitra United Heart Centre, Kasaragod, Kerala, India
  • Darshan Manohar Biradar Patil Department of Cardiology, Meitra United Heart Centre, Kasaragod, Kerala, India
  • Mohammed Sadan Department of Cardiology, Meitra United Heart Centre, Kasaragod, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20262206

Keywords:

Leadless pacemaker, Dual-chamber pacing, Sick sinus syndrome, Octogenarian, Femoral vein thrombosis, Cardiac rhythm management

Abstract

Leadless pacemaker technology has advanced to enable dual-chamber atrioventricular synchronous pacing through implant-to-implant communication between two independent leadless devices. We report the first AVEIR dual-chamber leadless pacemaker implantation performed at Meitra United Heart Centre (MUHC), marking a regional milestone for Kasaragod, Kannur, Coastal Karnataka, and Goa. An 86-year-old woman presented with sick sinus syndrome complicated by tachy-brady syndrome and presyncopal episodes. She underwent successful implantation of a dual-chamber leadless pacemaker via femoral venous access under general anesthesia using the Innvolution Pinnacle Agile Cath Lab at MUHC. Optimal electrical parameters were achieved, with a right ventricular threshold of 0.5 V at 0.4 ms and impedance of 750 Ω, and a right atrial threshold of 1.0 V at 0.4 ms and impedance of 310 Ω. Device-to-device communication was 100%. Postoperatively, the patient developed left femoral vein thrombosis, which was managed with anticoagulation therapy, and she was discharged in stable condition. This case demonstrates that dual-chamber leadless pacing is feasible in an octogenarian with sick sinus syndrome and may serve as an alternative to conventional transvenous pacing systems, while emphasizing the need to consider vascular access complications such as femoral vein thrombosis during patient selection.

References

Knops RE, Ip JE, Doshi R, Exner DV, Defaye P, Canby R, et al. One-Year Safety and Performance of a Dual-Chamber Leadless Pacemaker. Circ Arrhythm Electrophysiol. 2025;18(4):e013619.

Tjong FV, Reddy VY. Permanent Leadless Cardiac Pacemaker Therapy: A Comprehensive Review. Circulation. 2017;135(15):1458-70.

Knops RE, Reddy VY, Ip JE, Doshi R, Exner DV, Defaye P, et al. A Dual-Chamber Leadless Pacemaker. N Engl J Med. 2023;388(25):2360-70.

Steinwender C, Khelae SK, Garweg C, Chan JYS, Ritter P, Johansen JB, et al. Atrioventricular Synchronous Pacing Using a Leadless Ventricular Pacemaker: Results from the MARVEL 2 Study. JACC Clin Electrophysiol. 2020;6(1):94-106.

Reynolds D, Duray GZ, Omar R, Soejima K, Neuzil P, Zhang S, et al. A Leadless Intracardiac Transcatheter Pacing System. N Engl J Med. 2016;374(6):533-41.

Hayashi T, Shishido KS, Moriyama NM, Tobita KT, Murakami MM, Saito SS. Deep vein thrombosis after leadless pacemaker implantation. European Heart Journal. 2022;43(Suppl 2):ehac544.479.

Boveda S, Lenarczyk R, Haugaa KH, Iliodromitis K, Finlay M, Lane D, et al. Use of leadless pacemakers in Europe: results of the European Heart Rhythm Association survey. Europace. 2018;20(3):555-9.

Duray GZ, Ritter P, El-Chami M, Narasimhan C, Omar R, Tolosana JM, et al. Long-term performance of a transcatheter pacing system: 12-Month results from the Micra Transcatheter Pacing Study. Heart Rhythm. 2017;14(5):702-9.

Grubman E, Ritter P, Ellis CR, Giocondo M, Augostini R, Neuzil P, et al. To retrieve, or not to retrieve: System revisions with the Micra transcatheter pacemaker. Heart Rhythm. 2017;14(12):1801-6.

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Published

2026-06-29

How to Cite

U. G., B., Biradar Patil, D. M., & Sadan, M. (2026). First dual-chamber leadless pacemaker implantation at Meitra United Heart Centre, Kasaragod: a regional milestone in an octogenarian with sick sinus syndrome: a case report. International Journal of Research in Medical Sciences, 14(7), 3104–3106. https://doi.org/10.18203/2320-6012.ijrms20262206

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Section

Case Reports