Vertebral body changes that make spinal anesthesia difficult in geriatric patients

Authors

  • Harish Nukala Department of Anaesthesia and Operation Theatre Technology, School of Allied and Healthcare Sciences, Malla Reddy University, Hyderabad, Telangana, India
  • Ramalakshmi Tanuja Ghanta Department of Anaesthesia and Operation Theatre Technology, School of Allied and Healthcare Sciences, Malla Reddy University, Hyderabad, Telangana, India
  • Jyotsna Bhavani Chinthalapudi Department of Anaesthesia and Operation Theatre Technology, School of Allied and Healthcare Sciences, Malla Reddy University, Hyderabad, Telangana, India
  • Pallavi Koduru Department of Anaesthesia and Operation Theatre Technology, School of Allied and Healthcare Sciences, Malla Reddy University, Hyderabad, Telangana, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20262673

Keywords:

Spinal anaesthesia, Geriatric patients, Degenerative changes, Landmark identification, Failed block, Paramedian approach, Ultrasound-guided neuraxial blocks

Abstract

Spinal anaesthesia techniques are important, because age-related structural and degenerative alterations to the spine sometimes make it difficult to deliver spinal anaesthesia to the elderly population. The current understanding of age-related changes in the vertebral column that affect successful administration of spinal anaesthesia is thoroughly examined in this review. Our review focuses on the adverse effects of osteoporotic degenerative changes in older individuals, including reduced disc height, calcified ligaments, osteophyte formation, and narrowed interspinous spaces. These changes collectively complicate landmark identification and needle insertion and increase the risk of traumatic or failed spinal anaesthesia. Even though spinal anaesthesia is frequently a better option for older patients than general anaesthesia, age-related anatomical changes in the vertebral column present serious technical difficulties that can result in block failure and potentially requiring alternative or adapted approaches. The effectiveness of a number of adaptive techniques, including paramedian approaches, ultrasound-guided neuraxial blocks, and the use of alternate access sites in the sacral or lower lumbar spine, is analyzed further in this review. This review article additionally examines the challenges of delivering spinal anaesthesia to geriatric patients with altered spine structure, and investigates future directions in this field and notes a few limitations.

References

Silverstein JH, Rooke GA, Reves JG, McLeskey CH, editors. Geriatric anesthesiology. 2nd ed. Philadelphia: Elsevier Saunders; 2008: 278.

Al Harbi, Mohammed K, Alshaghroud S, Aljahdali MM, Ghorab F, Baba F, et al. Regional anesthesia for geriatric population. Saudi J Anesth. 2023;17(4):523-32.

Butterworth JF, Mackey DC, Wasnick JD. Spinal, epidural, and caudal blocks. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Cohen NH, Leslie K, eds. Miller’s Anesthesia. 9th ed. Philadelphia: Elsevier; 2019: 1697-738.

Orebaugh SL, Eng HC. Neuraxial anatomy (anatomy relevant to neuraxial anesthesia). In: Hadzic A, ed. Hadzic’s Textbook of Regional Anesthesia and Acute Pain Management. 2nd ed. New York: McGraw-Hill Education; 2017: 157-75.

Stier GR, Asgarzadie F, Cole DJ. Neurosurgical diseases and trauma of the spine and spinal cord: anesthetic considerations. In: Hagberg CA, Benumof JL, eds. Benumof and Hagberg’s Anesthesia. Philadelphia: Elsevier; 2021.

Karunarathna I, Godage S, Rodrigo PN, Jayawardana A, Vidanagama U, Fernando C, et al. Comprehensive review of spinal anaesthesia techniques. Uva Clin Anaesth Intensive Care. 2024.

University of Toronto. AnesthesiologyQR: regional anatomy. Toronto: University of Toronto. Available at: https://pie.med.utoronto.ca/anesthesiaqr/AnesthesiaQR_content/AnesthesiaQR_Regional_Anatomy.html. Accessed on 15 April 2026.

Spine-health. Osteoporosis. Available at: https://www.spine-health.com/conditions/osteoporosis. Accessed 31 March 2026. Accessed on 15 April 2026.

Lane NE. Epidemiology, etiology, and diagnosis of osteoporosis. Am J Obstet Gynecol. 2006;194(2): 3-11.

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). Osteoporosis. Bethesda (MD): NIAMS. Available at: https://www.niams.nih.gov/health-topics/osteoporosis. Accessed on 15 April 2026.

Scarcia L, Pileggi M, Camilli A, Romi A, Bartolo A, Giubbolini F, et al. Degenerative Disc Disease of the Spine: From Anatomy to Pathophysiology and Radiological Appearance, with Morphological and Functional Considerations. J Pers Med. 2022;12(11):1810.

Benoist M. Natural history of the aging spine. Eur Spine J. 2003;12(2):86-9.

Navone SE, Marfia G, Giannoni A, Beretta M, Guarnaccia L, Gualtierotti R, et al. Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol. 2017;32(6):523-42.

Teixeira GQ, Yong Z, Goncalves RM, Kuhn A, Riegger J, Brisby H, et al. Terminal complement complex formation is associated with intervertebral disc degeneration. Eur Spine J. 2021;30(1):217-26.

Abd Elfattah HM, El-Hossary ZI, Sayouh EF, Farmawy MS. Pre-procedure paramedian ultrasound-guided versus anatomical landmarks spinal anesthesia in elderly patients undergoing lower limb surgery. J Cardiovasc Dis Res. 2021;12(4).

Thangavelan M. Spine surgery under loco-regional anaesthesia in lateral decubitus position for an elderly patient-a risk mitigation approach. IMA Journal (Kauvery Hospital). 2024 Dec. Available at: https://www.kauveryhospital.com/ima-journal/ima-journal-december-2024/spine-surgery-under-loco-regional-anaesthesia-in-lateral-decubitus-position-for-an-elderly-patient-a-risk-mitigation-approach/. Accessed on 15 April 2026.

Kaur M, Aujla KS, Gosal JS. Anesthetic Challenges in a Patient with Severe Thoracolumbar Kyphoscoliosis. Anesth Essays Res. 2020;14(1):170-2.

Rustagi P. Patkar GA, Tendolkar BA. Management of a case of ankylosing spondylitis for percutaneous nephrolithotomy in prone position under combined spinal epidural anesthesia. Medical J D Y Patil Univer. 2016;9(6):765-7.

Nishikawa M, Yoshimura M, Naito K, Yamagata T, Goto H, Hara M, et al. The Symptomatic Calcification and Ossification of the Ligamentum Flavum in the Spine: Our Experience and Review of the Literature. J Clin Med. 2023;13(1):105.

Shetty N, Rajesh N, Aishwarya. Osteoporotic Compression Fracture with Anterolisthesis in a Geriatric Diabetic Patient: A Conservative Management Approach. Int J Scient Res Publ. 2025;15(12).

Chen PW, Chang CC, Tu TH, Wu JC, Huang WC. Acute Paraplegia Following Spinal Anesthesia in a Patient with Unrecognized Thoracic Ossification of the Posterior Longitudinal Ligament and Spinal Stenosis: A Case Report. Cureus. 2024;16(9):e68950.

Shu LP, Ji JM, Mao ZX. Epidemiologic investigation on neurological complications following neuraxial anesthesia in 2.7 million cases in Southwest China. Sci Rep. 2025;15:13497.

Narkhede HH, Kane D, Parekh V, Hemantkumar I. A cohort study of anatomical landmark-guided midline versus pre-procedure ultrasound-guided midline technique of spinal anesthesia in elderly patients undergoing orthopedic surgery. J Anaesthesiol Clin Pharmacol. 2019;35(4):522-7.

McLeod G, McCartney C, Wildsmith T. Principles and practice of regional anaesthesia. Oxford: Oxford University Press; 2012: 266.

Weinrich J, von Heymann C, Henkelmann A, Balzer F, Obbarius A, Ritschl PV, et al. Postdural puncture headache after neuraxial anesthesia: incidence and risk factors. Anaesthesist. 2020;69(12):878-85.

Sivevski AG, Karadjova D, Ivanov E, Kartalov A. Neuraxial Anesthesia in the Geriatric Patient. Front Med (Lausanne). 2018;5:254.

Pozza DH, Tavares I, Cruz CD, Fonseca S. Spinal Cord Injury and Complications Related to Neuraxial Anaesthesia Procedures: A Systematic Review. Int J Mol Sci. 2023;24(5):4665.

Ahsan-ul-Haq M, Amin S, Javaid S. Paramedian technique of spinal anesthesia in elderly patients for hip fracture surgery. J Coll Physicians Surg Pak. 2005;15(3):160-1.

Kim SY, Na HS, Park JI, Lee KO, Shin HJ. Comparison of the Effect of Landmark-Based Midline and Paramedian Approaches on Spinal Anesthesia-Related Complications in Adult Patients: A Meta-Analysis of Randomized Controlled Trials. Medicina (Kaunas). 2024;60(1):178.

Rabinowitz A, Bourdet B, Minville V, Chassery C, Pianezza A, Colombani A, Eychenne B, Samii K, Fourcade O. The paramedian technique: a superior initial approach to continuous spinal anesthesia in the elderly. Anesth Analg. 2007;105(6):1855-7.

NYSORA. Spinal anesthesia. 2018. New York School of Regional Anesthesia; Available at: https://www.nysora.com/techniques/spinal-anesthesia-2/. Accessed on 15 April 2026.

Gonçalves D, Roriz D, Teixeira F. Taylor´s approach to subarachnoid block in an elderly patient: a solution after failed conventional approach. Reg Anesth Pain Med. 2021;70:36.

Using Lumbar X-Ray to Facilitate Modified Taylor's Approach of Spinal Anesthesia in an Elderly Patient With Scoliosis. Cureus. 2021;13(1):e12556.

Paria R, Surroy S, Majumder M, Paria B, Paria A, Das G. Sacral spinal anaesthesia. Indian J Anaesth. 2014;58(1):80-2.

Dua A, Afzal M. Caudal Anesthesia. Treasure Island (FL): StatPearls Publishing; 2026.

Axmann K, Pieran M, Berta E, Gabrhelík T. Caudal block in adult patients and its use in the perioperative period. Anest. intenziv. Med. 2019;30(1):33-8.

Papadakis M, Sapkas G, Papadopoulos EC, Katonis P. Pathophysiology and biomechanics of the aging spine. Open Orthop J. 2011;5:335-42.

Perlas A, Chaparro LE, Chin KJ. Lumbar neuraxial ultrasound for spinal and epidural anesthesia: a systematic review and meta-analysis. Reg Anesth Pain Med. 2016;41:251-60.

NYSORA. Introduction to ultrasound-guided regional anesthesia, 2018. Available at: https://www.nysora.com/topics/equipment/introduction-ultrasound-guided-regional-anesthesia/. Accessed on 15 April 2026.

Sahana Patil DSP, Charulatha DC, Vishal Patil DVP. A Prospective Study Comparing Landmark Technique Versus Preprocedure Ultrasound-Guided Paramedian Spinal Anaesthesia in the Elderly. Int J Med Pharmaceut Res. 2025 Jul;6(4):1512-6.

Cao MM, Zhang YW, Sheng RW, Gao W, Kang QR, Gao YC, et al. General Anesthesia Versus Regional Anesthesia in the Elderly Patients Undergoing Hip Fracture Surgeries: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. World J Surg. 2023;47(6):1444-56.

Sasagawa T, Murakami H, Maruhashi Y, Segawa T, Yamamoto D, Shimizu S, et al. Iatrogenic Lumbar Vertebral Fracture during Osteosynthesis for a Trochanteric Fracture of the Femur in Diffuse Idiopathic Skeletal Hyperostosis. Asian Spine J. 2015;9(5):803-6.

Yoo S, Han Y, Kim Y, Park SK, Lim YJ, Kim JT. Influence of laminectomy on the lumbosacral cerebrospinal fluid volume: A retrospective magnetic resonance imaging study. Anaesth Intensive Care. 2023;51(4):254-9.

Hajmurad S, Rifai KJ, Perez AA, Hall A. Epidural Hematoma in an Elderly Patient With Multiple Comorbidities on Aspirin Following Spinal Cord Stimulator Trial: A Case Report. Pain Med Case Rep. 2025;9(3):161-4.

Finger A, Rapsas B, Karayi E, Han J, Ramanujam V. Post-dural Puncture Headache Complicated by Subdural Hematoma in an Elderly Patient Following a Pencil-Point Spinal Needle Anesthesia: A Case Report. Cureus. 2026;18(3):105887.

Pozza DH, Tavares I, Cruz CD, Fonseca S. Spinal Cord Injury and Complications Related to Neuraxial Anaesthesia Procedures: A Systematic Review. Int. J. Mol. Sci. 2023;24:4665.

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Published

2026-07-30

How to Cite

Nukala, H., Tanuja Ghanta, R., Chinthalapudi, J. B., & Koduru, P. (2026). Vertebral body changes that make spinal anesthesia difficult in geriatric patients. International Journal of Research in Medical Sciences, 14(8), 3691–3701. https://doi.org/10.18203/2320-6012.ijrms20262673

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Section

Review Articles