A study on the association between HSV-2 and HIV serostatus in HIV seropositive and HIV seronegative individuals

Ravichitra Katta Naga, Satyanarayana Oruganti


Background: HSV-2 is a common cause of genital ulcer disease worldwide and has become a prominent public health issue over recent years. The major public health importance of HSV-2 relates to its potential role in facilitating HIV transmission. This study was done to know the association of HSV-2 and HIV, to compare the seropositivity of HSV-2 in HIV seropositive and HIV seronegative individuals and also to study the influence of certain factors on HSV-2 infection.

Methods: Blood samples collected from 132 HIV seropositive individuals and 50 HIV seronegative blood donors were screened for HSV-2 type specific IgG antibodies by ELISA.

Results: 84 samples of the test group tested positive for HSV-2 (63.63%), which is significantly higher compared to 3 (6%) positives of the control group. HSV-2 seropositivity was significantly higher in individuals with multiple sexual partners, illiterates, daily wage workers.

Conclusions: High seropositivity of HSV-2 in HIV seropositive individuals demonstrates the need for regular screening of HSV-2 in HIV seropositive individuals. It also clearly shows that education and occupation will influence the prevalence of HIV and HSV-2.  


HSV-2, HIV, ELISA, Seropositivity

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