Evaluation of hepatitis B vaccine responsiveness in ‎hemodialysis and peritoneal dialysis patients

Authors

  • Salama Elsayed Farag Department of Internal Medicine, Nephrology Unit, Zagazig University, Zagazig
  • Tarek A. Ghonemy Department of Internal Medicine, Nephrology Unit, Zagazig University, Zagazig
  • Sameh A. Soliman Department of Internal Medicine, Nephrology Unit, Zagazig University, Zagazig
  • Ahmed Bihery Department of Tropical Medicine, Zagazig University, Zagazig

DOI:

https://doi.org/10.18203/2320-6012.ijrms20150613

Keywords:

End stage renal disease, Hepatitis B virus, Vaccine

Abstract

Background: Hepatitis B Virus (HBV) infection is considered as a major cause of liver cirrhosis and hepatocellular carcinoma. Patients with End Stage Renal Disease (ESRD) are a risk group for HBV infection. The vaccine of hepatitis B has been recommended for prevention of HBV infection in ESRD patient especially on renal replacement therapy.  

Methods: Eighty seven patients with ESRD on peritoneal ‎dialysis and hemodialysis requiring primary hepatitis B vaccination were ‎enrolled in the study. Each of them received 40 µg of recombinant hepatitis B ‎vaccine in a four-dose schedule. Antibody response was determined by the ‎levels of antibodies to the hepatitis B surface antigen (anti-HBs) after last ‎doses of the vaccination schedule.  

Results: We observed three response patterns to the immunizations in all patients after vaccination, the nonresponders (24.7%) never reached the minimum protective titer of 10 mIU/mL, the poor responders (18.5%) had titers between 10 and 100 mIU/mL, and the good responders (56.8%) had antibody titers above 100 mIU/mL. Despite a reduction in anti-HBs over time, the good responders did not become unprotected during the observation period, especially those participants who had titers above 1000 mIU/mL after the initial immunization.  

Conclusions: We concluded that the immune ‎response of the HBV vaccine was reduced in the HD and PD patients, which ‎need yearly re-evaluation of seroconversion with booster doses of HBV ‎vaccination if needed‎.

 

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Published

2017-01-12

How to Cite

Farag, S. E., Ghonemy, T. A., Soliman, S. A., & Bihery, A. (2017). Evaluation of hepatitis B vaccine responsiveness in ‎hemodialysis and peritoneal dialysis patients. International Journal of Research in Medical Sciences, 3(9), 2259–2263. https://doi.org/10.18203/2320-6012.ijrms20150613

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Original Research Articles