Published: 2017-03-28

Evaluation of diffuse lung diseases by high resolution computed tomography of chest

Poonam Vohra, Harsumeet S. Sidhu


Background: Diffuse lung diseases describe a heterogeneous group of disorders of the lower respiratory tract characterized by inflammation and derangement of the interstitium and loss of functional alveolar units. The disease is not restricted to the interstitium only, as it involves epithelial, endothelial and mesenchymal cells with the disease process extending into the alveoli, acini and bronchioles. Thus, the entire pulmonary parenchyma is involved. The objective of the study was to evaluate diffuse lung diseases by high resolution computed tomography of chest.

Methods: A cross-sectional observational study was done in 30 patients. Adult patients of either sex of age group 18 and above showing reticular opacities on chest X-ray and those patients who were incidentally diagnosed as cases of diffuse lung diseases on HRCT chest were included in present study.

Results: Reticular opacities were the most common roentgenographic finding followed by reticulonodular opacities. On HRCT, intra and interlobular septal thickening was the most common finding in Idiopathic interstitial pneumonia (usual interstitial pneumonia).

Conclusions: High resolution computed tomography (HRCT) is superior to the plain chest X-ray for early detection and confirmation of suspected diffuse lung diseases. In addition, HRCT allows better assessment of the extent and distribution of disease, and it is especially useful in the investigation of patients with a normal chest radiograph. Coexisting disease is often best recognized on HRCT scanning.


Computed tomography, Diffuse lung diseases, High resolution

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American Thoracic Society/European Respiratory Society. International Multidisciplinary Consensus Classification of the Idiopathic International Pneumonias. Am J Respir Crit Care Med. 2002;165:277-304.

Staples CA, Muller NL, Vedal S, Abboud R. Usual interstitial pneumonia: correlation of CT with clinical, functional and radiologic findings. Radiology. 1987;162:377-81.

Fulmer JD, Crystal RG. Interstitial lung diseases. Curr Pulmonol. 1979;1:1-65.

Mawson JB, Muller NL, Mathieson Jr. Sarcoidosis- correlation of extent of disease at CT with clinical, functional and radiographic findings. Radiology. 1989;171:613-8.

Ryu JH, Colby TV, Hartmann TE. Smoking related interstitial lung diseases: A Review. Eur Resp J 2001;17:122-32.

Epler GE, Carrington CB, Gaensler EA. Crackles in interstitial pulmonary diseases. Chest. 1978;73:333-9

Epler GE, Carrington CB, Gaensler EA. Crackles in interstitial pulmonary diseases. Chest. 1978;73:333-9.

Chinet T, Dusser D, Labrune S, Collignon MA, Chretien J, Huchon GJ. Lung Function declines in patients with Pulmonary sarcoidosis and increased respiratory epithelial permeability to 99mTc-DTPA. Am Rev Resp Dis. 1990;141(2):445-9.

Nishimura k, Kitaichi M, Izumi T. UIP- histologic correlation with high resolution computed tomography. Radiology. 1992;182:337-42.

Remy-Jardin M, Remy J. Pulmonary involvement in progressive systemic sclerosis: sequential evaluation with CT, pulmonary function tests and bronchioalveolar lavage. Radiology. 1993;188:499-506.

Leung AN, Miller RR, Muller NL. Pulmonary opacities in chronic infiltrative lung diseases: CT- pathologic correlation. Radiology. 1993;188:209-14.

Cottin V, Donsbeck AV, Loire R, Cordier JF. Nonspecific interstitial pneumonia: Individualisation of a clinicopathologic entity in a series of 12 patients. Am J Resp Crit Care Med. 1998;158(4):1286.

Ryu JH, Myers JL, Capizzi SA, Douglas WW, Vassallo R, Decker PA. Desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease. Chest. 2005;127(1):178-84.

Akira M, Sakatani M, Hara H. Thin section CT findings in rheumatoid arthritis-associated lung disease: CT patterns and their courses. J Comp Assist Tomogr. 1999;23(6):941-8.

Tanaka M, Kim JS, Newell JD, Brown KK, Cool CD, Meehan R, et al. Rheumatoid arthritis- related lung diseases: CT findings. Radiology. 2004;232(1):81-91.

Schurawitzki H, Stiglbauer R, Graninger W, Herold C, Polzleitner D, Burghuber OC. Interstitial lung disease in progressive systemic sclerosis: HRCT vs radiography. Radiology. 1990 Sep;176(3):755-9.

Muller N, Staples C, Miller R, Vedal S, Thurlbeck W, Ostrow D. Disease activity in idiopathic pulmonary fibrosis: CT and pathologic correlation. Radiology. 1987;165:731-4.

Remy-Jardin M, Giraud F, Remy J, Copin MC, Gosselin B, Duhamel A. Importance of ground glass attenuation in chronic diffuse infiltrative lung disease: pathologic- CT correlation. Radiology. 1993;189:693-8.

Nishimura K, Kitaichi M, Izumi T, Nagai S, Kanaoka M, Itoh H. Usual Interstitial pneumonia: histologic correlation with high resolution CT. Radiology. 1992;182:337-42.

Teriff BA, Kwan SY, Chan-Yeung MM, Mueller NL. Fibrosingalveolitis: chest radiology and CT as predictors of clinical and functional impairment at follow-up in 26 patients. Radiology. 1993;184:1076-82.

Gay SE, Kazerooni EA, Toews GB, Lynch J, Gross BH, Cascade PN, et al. Idiopathic pulmonary fibrosis: predicting response to therapy and survival. Am J Respir Crit Care Med. 1998;157:1063-72.

Staples C, Muller N, Vedal S, Abboud R, Ostrow D, Miller R. Usual interstitial pneumonia: correlation of CT with clinical, functional and radiographic findings. Radiology. 1987;162:377-81.