Nanotechnology in dental implantology

Authors

  • Shajahan P. A. Department of Prosthodontics, Royal Dental College, Palakkad, Kerala, India
  • Rohit Raghavan Department of Prosthodontics, Royal Dental College, Palakkad, Kerala, India
  • Sreehari S. Department of Prosthodontics, Royal Dental College, Palakkad, Kerala, India

DOI:

https://doi.org/10.18203/2320-6012.ijrms20263139

Keywords:

Nanotechnology, Dental implants, Osseointegration

Abstract

Nanotechnology has expanded dental implant surface engineering from conventional macro- and microscale modification to deliberate control of surface characteristics at the nanometre scale. Nanostructured surfaces can modify surface chemistry, energy, roughness, wettability and topography, thereby influencing protein adsorption, cellular adhesion, differentiation and bone formation. Titanium and its alloys remain the principal materials for endosseous dental implants, while nanoscale modification using titanium dioxide nanotubes, hydroxyapatite, calcium phosphate, metallic nanoparticles, bioactive glass, polymers and hybrid coatings has been investigated to improve biological performance. Systematic evidence supports promising preclinical antibacterial effects of TiO₂ nanotubes, but clinical translation remains limited. Studies also emphasize the potential of nano-engineered surfaces to modulate inflammation, osteogenesis, corrosion resistance and localized drug delivery.

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References

Pye AD, Lockhart DE, Dawson MP, Murray CA, Smith AJ. A review of dental implants and infection. J Hospital Infect. 2009;72(2):104-10. DOI: https://doi.org/10.1016/j.jhin.2009.02.010

Christenson EM, Anseth KS, van den Beucken JJ, Chan CK, Ercan B, Jansen JA, et al. Nanobiomaterial applications in orthopedics. J Orthop Res. 2007;25(1):11-22. DOI: https://doi.org/10.1002/jor.20305

Lavenus S, Ricquier JC, Louarn G, Layrolle P. Cell interaction with nanopatterned surface of implants. Nanomedicine. 2010;5(6):937-47. DOI: https://doi.org/10.2217/nnm.10.54

Ercan B, Taylor E, Alpaslan E, Webster TJ. Diameter of titanium nanotubes influences anti-bacterial efficacy. Nanotechnology. 2011;22(29):295102. DOI: https://doi.org/10.1088/0957-4484/22/29/295102

Kummer KM, Taylor EN, Durmas NG, Tarquinio KM, Ercan B, Webster TJ. Effects of different sterilization techniques and varying anodized TiO2 nanotube dimensions on bacteria growth. J Biomed Materials Res Part B: Applied Biomaterials. 2013;101(5):677-88. DOI: https://doi.org/10.1002/jbm.b.32870

Zhang H, Sun Y, Tian A, Xue XX, Wang L, Alquhali A, et al. Improved antibacterial activity and biocompatibility on vancomycin-loaded TiO2 nanotubes: in vivo and in vitro studies. Int J Nanomed. 2013;8:4379-89. DOI: https://doi.org/10.2147/IJN.S53221

Cordeiro JM, Barão VA. Is there scientific evidence favoring the substitution of commercially pure titanium with titanium alloys for the manufacture of dental implants? Materials Science and Engineering: C. 2017;71:1201-15. DOI: https://doi.org/10.1016/j.msec.2016.10.025

Osman RB, Swain MV. A critical review of dental implant materials with an emphasis on titanium versus zirconia. Materials. 2015;8(3):932-58. DOI: https://doi.org/10.3390/ma8030932

Carinci F, Pezzetti F, Volinia S, Francioso F, Arcelli D, Farina E, et al. Zirconium oxide: analysis of MG63 osteoblast-like cell response by means of a microarray technology. Biomaterials. 2004;25(2):215-28. DOI: https://doi.org/10.1016/S0142-9612(03)00486-1

Chevalier J. What future for zirconia as a biomaterial? Biomaterials. 2006;27(4):535-43. DOI: https://doi.org/10.1016/j.biomaterials.2005.07.034

Katunar MR, Sanchez AG, Coquillat AS, Civantos A, Campos EM, Ballarre J, et al. In vitro and in vivo characterization of anodised zirconium as a potential material for biomedical applications. Materials Science and Engineering: C. 2017;75:957-68. DOI: https://doi.org/10.1016/j.msec.2017.02.139

Sartoretto SC, Calasans-Maia J, Resende R, Câmara E, Ghiraldini B, Barbosa Bezerra FJ, et al. The influence of nanostructured hydroxyapatite surface in the early stages of osseointegration: a multiparameter animal study in low-density bone. Int J Nanomed. 2020;15:8803-17. DOI: https://doi.org/10.2147/IJN.S280957

Ono D, Jimbo R, Kawachi G, Ioku K, Ikeda T, Sawase T. Lateral bone augmentation with newly developed β‐tricalcium phosphate block: an experimental study in the rabbit mandible. Clin Oral Implants Res. 2011;22(12):1366-71. DOI: https://doi.org/10.1111/j.1600-0501.2010.02117.x

Bao L, Liu J, Shi F, Jiang Y, Liu G. Preparation and characterization of TiO2 and Si-doped octacalcium phosphate composite coatings on zirconia ceramics (Y-TZP) for dental implant applications. Appl Surface Sci. 2014;290:48-52. DOI: https://doi.org/10.1016/j.apsusc.2013.10.185

Stefanic M, Krnel K, Pribosic I, Kosmac T. Rapid biomimetic deposition of octacalcium phosphate coatings on zirconia ceramics (Y-TZP) for dental implant applications. Appl Surface Sci. 2012;258(10):4649-56. DOI: https://doi.org/10.1016/j.apsusc.2012.01.048

Joy-anne NO, Su Y, Lu X, Kuo PH, Du J, Zhu D. Bioactive glass coatings on metallic implants for biomedical applications. Bioactive Materials. 2019;4:261-70. DOI: https://doi.org/10.1016/j.bioactmat.2019.09.002

Rasouli R, Barhoum A, Uludag H. A review of nanostructured surfaces and materials for dental implants: surface coating, patterning and functionalization for improved performance. Biomaterials Sci. 2018;6(6):1312-38. DOI: https://doi.org/10.1039/C8BM00021B

Dalby MJ, Riehle MO, Johnstone HJ, Affrossman S, Curtis AS. Polymer-demixed nanotopography: control of fibroblast spreading and proliferation. Tissue Engineering. 2002;8(6):1099-108. DOI: https://doi.org/10.1089/107632702320934191

Zheng Y, Li J, Liu X, Sun J. Antimicrobial and osteogenic effect of Ag-implanted titanium with a nanostructured surface. Int J Nanomed. 2012;7:875-84. DOI: https://doi.org/10.2147/IJN.S28450

Pachauri P, Bathala LR, Sangur R. Techniques for dental implant nanosurface modifications. J Adv Prosthodont. 2014;6(6):498. DOI: https://doi.org/10.4047/jap.2014.6.6.498

Tomsia AP, Launey ME, Lee JS, Mankani MH, Wegst UG, Saiz E. Nanotechnology approaches for better dental implants. Int J Oral Maxillof Implants. 2011;26(1):25.

Botticelli D, Lang NP. Dynamics of osseointegration in various human and animal models‐a comparative analysis. Clin Oral Implants Res. 2017;28(6):742-8. DOI: https://doi.org/10.1111/clr.12872

Kulkarni M, Mazare A, Schmuki P, Iglič A, Seifalian A. Biomaterial surface modification of titanium and titanium alloys for medical applications. Nanomedicine. 2014;111(615):111.

Curtis A, Wilkinson C. Nantotechniques and approaches in biotechnology. TRENDS Biotechnol. 2001;19(3):97-101. DOI: https://doi.org/10.1016/S0167-7799(00)01536-5

Dalby MJ, Gadegaard N, Tare R, Andar A, Riehle MO, Herzyk P, et al. The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder. Nature Materials. 2007;6(12):997-1003. DOI: https://doi.org/10.1038/nmat2013

Anselme K, Bigerelle M. Statistical demonstration of the relative effect of surface chemistry and roughness on human osteoblast short-term adhesion. J Materials Sci. 2006;17(5):471-9. DOI: https://doi.org/10.1007/s10856-006-8475-8

Jandt KD, Watts DC. Nanotechnology in dentistry: Present and future perspectives on dental nanomaterials. Dental Materials. 2020;36(11):1365-78. DOI: https://doi.org/10.1016/j.dental.2020.08.006

Zhang Y, Gulati K, Li Z, Di P, Liu Y. Dental implant nano-engineering: advances, limitations and future directions. Nanomaterials. 2021;11(10):2489. DOI: https://doi.org/10.3390/nano11102489

Silva RC, Agrelli A, Andrade AN, Mendes-Marques CL, Arruda IR, Santos LR, et al. Titanium dental implants: an overview of applied nanobiotechnology to improve biocompatibility and prevent infections. Materials. 2022;15(9):3150. DOI: https://doi.org/10.3390/ma15093150

Wu B, Tang Y, Wang K, Zhou X, Xiang L. Nanostructured titanium implant surface facilitating osseointegration from protein adsorption to osteogenesis: the example of TiO2 NTAs. Int J Nanomed. 2022;17:1865-79. DOI: https://doi.org/10.2147/IJN.S362720

Accioni F, Vázquez J, Merinero M, Begines B, Alcudia A. Latest trends in surface modification for dental implantology: Innovative developments and analytical applications. Pharmaceutics. 2022;14(2):455. DOI: https://doi.org/10.3390/pharmaceutics14020455

Fontelo R, Soares da Costa D, Gomez-Florit M, Tiainen H, Reis RL, Novoa-Carballal R, et al. Antibacterial nanopatterned coatings for dental implants. J Materials Chem B. 2022;10(42):8710-8. DOI: https://doi.org/10.1039/D2TB01352E

Gulati K, Chopra D, Kocak-Oztug NA, Verron E. Fit and forget: the future of dental implant therapy via nanotechnology. Adv Drug Delivery Rev. 2023;199:114900. DOI: https://doi.org/10.1016/j.addr.2023.114900

Kunrath MF, Farina G, Sturmer LB, Teixeira ER. TiO2 nanotubes as an antibacterial nanotextured surface for dental implants: systematic review and meta-analysis. Dental Materials. 2024;40(6):907-20. DOI: https://doi.org/10.1016/j.dental.2024.04.009

Ghodrati H, Goodarzi A, Golrokhian M, Fattahi F, Anzabi RM, Mohammadikhah M, et al. A narrative review of recent developments in osseointegration and anti-corrosion of titanium dental implants with nano surface. Bone Rep 2025;25:101846. DOI: https://doi.org/10.1016/j.bonr.2025.101846

Joseph B, Sultan N, Jayash SN. Can the use of silver nanoparticles in dental implants increase its antimicrobial potency?-systematic review. BMC Oral Health. 2025;25(1):1221. DOI: https://doi.org/10.1186/s12903-025-06487-0

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Published

2026-08-29

How to Cite

P. A., S., Raghavan, R., & S., S. (2026). Nanotechnology in dental implantology. International Journal of Research in Medical Sciences, 14(9), 4124–4129. https://doi.org/10.18203/2320-6012.ijrms20263139

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Section

Review Articles