Outcome and management of antenatal patients with jaundice in tertiary care centre of eastern India: a retrospective study

Kalpana Singh, Gopal Kumar, Anshu Singh, Anjali Rani


Background: Aim of current study was to know the etiological factors of jaundice among pregnant patients, outcome and their management.

Methods: A retrospective study done at IMS, BHU in obstetrics and gynecology department among pregnant patients with jaundice admitted in obstetric wards and labour room in six months duration.  

Results: Among total 1960 admissions, 78 (3.97%) patients presented with jaundice. Out of all admissions 27 (1.37%) were HBSAg, 8 (0.40%) HEV, 7 (0.35%) HCV, 6 (0.30%) of HBSAg and HEV co-infection, cholestasis with pregnancy 20 (1%) and 10 (0.51%) patients with pre-eclamptic liver disease with HELLP.

Conclusions: Jaundice in pregnancy may be lethal to mother and fetus. As the course of disease is also rapid and in short period it may affect the fetus in utero also, early detection and prompt management of these cases should be done.  


Pregnancy, Jaundice, Viral markers, Hepatic encephalopathy

Full Text:



Hay JE. Liver disease in pregnancy. Hepatology. 2008;47(3):1067-76.

Creasy RK, Resnik R. Jaundice. In: Creasy RK, Resnik R, eds. Maternal Fetal Medicine: Principles and Practice. 5th ed. Philadelphia: WB Saunders; 2004: 713.

Shalimar, Sulrat K. Acharya. Hepatitis E and acute liver failure in pregnancy. J Clin Exp Hepatol. 2013;3(3):213-24.

Lata I. Hepatobiliary diseases during pregnancy and their management: an update. Int J Crit Illn Inj Sci. 2013;3(3):175-82.

Goel A, Jamwal KD, Ramachandran A, Balasubramanian KA, Eapen CE. Pregnancy-related liver disorders. J Clin Exp Hepatol. 2014;4(2):151-62.

Oladokun A, Otegbayo JA, Adeniyi AA. Maternal and fetal outcomes of jaundice in at pregnancy the University College Hospital, Ibadan. Niger J Clin Pract. 2009;12(3):277-80.

Joshi D, James A, Quaglia A, Westbrook RH, Heneghan MA. Liver disease in pregnancy cholestasis. Lancet. 2010;375:594-605.

Nagaria Tripti, Agarwal S. Fetomaternal outcome in jaundice during pregnancy. Obstet Gynecol India. 2005;55(5):424-7.

Sapre S, Joshi V. Changing trends of maternal mortality in North M.P. J Obstet Gynecol. 2009;49:53-6.