AI in patient education: a cross-sectional comparative analysis of patient information guides produced by ChatGPT versus Google Gemini for common haematology conditions
DOI:
https://doi.org/10.18203/2320-6012.ijrms20264170Keywords:
Vitamin B12 deficiency, Patient education, Iron deficiency anaemia, Haematology, Artificial intelligence, ChatGPT, Google GeminiAbstract
Background: Haematological disorders encompass a diverse range of conditions affecting blood and blood-forming organs. Educating Patients is crucial in managing these disorders, enabling individuals to understand their conditions, associated complications, and preventive measures. As artificial intelligence (AI) continues to progress, chatbots such as ChatGPT (CG) and Google Gemini (GG) offer readily available patient information.
Methods: This cross-sectional comparative study was performed from January 15, 2025, to January 22, 2025. Six haematological conditions were selected. Patient education materials were created using CG (version 4.0) and GG, following standardized prompts. The generated texts were analysed for readability, similarity, and reliability with the use of Flesch-Kincaid Calculator (FKC), Quill Bot Plagiarism Tool (QPT) and Modified DISCERN score, respectively.
Results: The study demonstrated no significant difference between the CG and GG in word count (WC), sentence count (SC), readability score, or reliability score in the statistical evaluation. The CG demonstrated a slightly higher ease-of-understanding score, but this difference was not statistically significant (p=0.175).
Conclusions: AI tools including CG and GG have an important role in educating patients by delivering quick and structured information on haematological conditions. Future studies should explore the role of AI in other medical domains and investigate ways to enhance AI-generated patient education materials.
References
Van Stavern GP, Smith LD, James HR. Hematologic disorders. Albert Jakobiec's Princi Pract Ophthalmol. 2021:1-40.
2. Warner MJ, Kamran MT. Iron deficiency anaemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
Ankar A, Kumar A. Vitamin B12 deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
Mangla A, Ehsan M, Agarwal N. Sickle cell anaemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.
Bajwa H, Basit H. Thalassemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.
Mehta P, Reddivari AKR. Hemophilia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.
Chennamadhavuni A, Iyengar V, Mukkamalla SKR, Shimanovsky A. Leukemia. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2023.
OpenAI. ChatGPT: Optimizing language models for dialogue, 2023. Available at: https://openai.com/chatgpt. Accessed 02 April 2026.
Guinness H. What is Google Gemini? What you need to know, 2024. Available at: https://zapier.com/blog/google-gemini/. Accessed 02 April 2026.
Morrissey M, McLaughlin J, O'Connor Y. Reporting of ethical considerations in qualitative research using social media data. J Med Internet Res. 2024;26:e51496.
Deoghare S. Virtual research designs and IRB requirements: clarifying what truly needs ethics approval. Minerva Med. 2026;117(2):96-7.
OpenAI. ChatGPT, 2025. Available at: https://chatgpt.com/. Accessed 02 April 2026.
Google. Gemini-Chat to supercharge your ideas, 2024 Available at: https://gemini.google.com/. Accessed 02 April 2026.
Good Calculators. Flesch Kincaid Calculator, 2019 Available at: https://goodcalculators.com/flesch-kincaid-calculator/. Accessed 02 April 2026.
Quill Bot, Plagiarism checker, 2026. Available at: https://quillbot.com/plagiarism-checker. Accessed 02 April 2026.
Li HOY, Bailey A, Huynh D, Chan J. YouTube as a source of information on COVID-19: a pandemic of misinformation? BMJ Glob Health. 2020;5(5):e002604.
Didier AJ, Moss G, Sutton JM. Applications of artificial intelligence for cancer patient education. J Cancer Educ. 2025;40(3):313.
Kirchner GJ, Kim RY, Weddle JB, Bible JE. Can artificial intelligence improve the readability of patient education materials? Clin Orthop Relat Res. 2023;481(11):2260-7.
Gül Ş, Erdemir İ, Hancı V, Aydoğmuş E, Erkoç YS. How artificial intelligence can provide information about subdural hematoma: assessment of readability, reliability, and quality of chatbot responses. Medicine (Baltimore). 2024;103(18):e38009.
Carlson JA, Cheng RZ, Lange A, Nagalakshmi N, Rabets J, Shah T, et al. Accuracy and readability of artificial intelligence chatbot responses to vasectomy-related questions: public beware. Cureus. 2024;16(8):e67996.
Ghanem YK, Rouhi AD, Al-Houssan A, Saleh Z, Moccia MC, Joshi H, et al. Dr Google to Dr ChatGPT: assessing the content and quality of artificial intelligence-generated medical information on appendicitis. Surg Endosc. 2024;38(5):2887-93.
Warn M, Meller LL, Chan D, Torabi SJ, Bitner BF, Tajudeen BA, et al. Assessing the readability, reliability, and quality of AI-modified patient education materials for endoscopic skull base surgery. Am J Rhinol Allergy. 2024;38(6):396-402.
Golan R, Ripps SJ, Reddy R, Loloi J, Bernstein AP, Connelly ZM, et al. ChatGPT's ability to assess quality and readability of online medical information: a cross-sectional study. Cureus. 2023;15(7):e42214.
Szczesniewski JJ, Tellez Fouz C, Ramos Alba A, Diaz Goizueta FJ, García Tello A, Llanes González L. ChatGPT and most frequent urological diseases: analysing the quality of information and potential risks for patients. World J Urol. 2023;41(11):3149-53.
Paluszek O, Loeb S. Artificial intelligence and patient education. Curr Opin Urol. 2025;35(2):126-31.
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Copyright (c) 2026 Sri Harini S., Himabindu Dande, Sujitha Nagabhyru, Ayesha Shafiya, Anjana Kurian, Eda Sai Venkata Teja, Nithin Reji

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