DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20171283

Comparison between sepsis markers and blood culture in diagnosis of neonatal sepsis: a prospective study

Vijay Baburao Sonawane, Nitin Mehkarkar, Sonali Gaikwad, Nitin Kadam

Abstract


Background: Neonatal septicaemia is one of the commonest causes of neonatal mortality and morbidity. Accurate and timely diagnosis of neonatal sepsis remains a major challenge to the pediatricians and neonatologists. In the present study, correlation between sepsis screening and blood culture in neonate presenting with features of sepsis is done to accelerate the diagnostic process and blood culture (considered gold standard) was evaluated as marker for sepsis detection and its effectiveness was compared with other septic markers.

Methods: In present study, we emphasize to study early indicators of sepsis screen and their statistical correlation with blood culture (considered as gold standard).

Results: As any sepsis screen parameters showed little correlation with blood culture, yet on combination it was found that specificity and positive predictive accuracy increased while sensitivity decreased them individual tests. Also combination of tests yield better results than single tests.

Conclusions: The combination of sepsis makers yielded diagnostic results than single tests and proved to be an invaluable aid for early diagnosis of neonatal sepsis.


Keywords


Blood culture, Neonatal sepsis, Sepsis screen

Full Text:

PDF

References


National Neonatology Forum. Report of National Neonatal Perinatal Database 2000, New Delhi. Available at: http://www.newbornwhocc.org/ pdf/ nnpd_report_2002-03.PDF.

Meherban S. Perinatal Infections. In: Care of Newbown. Sagar Publication, New Delhi. 2010;7:223-33.

Buetow KC. Septicemia in premature infant. Am J Dis Child. 1965;110(1):29-41.

Bhakoo ON. Neonatal bacterial infections at Chandigarh. A decade of experience. Ind J Ped. 1980;47:419-24.

Waaga A, Brandtzaeg P, Hatstensen P. The complex patter of cytokines in serum from patients with meningococcal septic shock. J Exp Med. 1989;169:333-8.

Jeevasankar M, Agarwal R, Deorari A, Paul VK. Sepsis in Newborn. Ind J Ped. 2008;75(3):261-6.

Stoll Barbara J. Infections of the neonatal infant. In: Kliegman RM, Behrman RE, Jenson HB editors. Nelson’s Textbook of Pediatrics. 18th edition. Philadelphia, Saunders. 2007:794-811.

Faridi MMA, Gupta P, Bhargava SK. Chest radiograph in neonatal sepsis. Ind. Ped. 1972;(29):871.

Washburn TC, Medeasis DN, Childs B. Sex difference in susceptibility to infection. Pediatrics. 1965;35(1):57.

Jain NK, Jain VM, Maheshwari S. Clinical Profile of Neonatal Sepsis. Kathmandu Univ Med J. 2003(1): 117-20.

Philip AGS. The changing face of neonatal infection: experience at a regional medical center. Pediatr Inf Dis J. 1994(13):1098-102.