Does thyroid function have any relation with components of metabolic syndrome?

Authors

  • Yash Shah Research assistant, Valley Hospital, New Jersey
  • Abhishek Vadher Visiting Scientist, Feinstein Institute for Medical Research, New York
  • Karthik Reddy Research assistant, MD Anderson Cancer Clinic, Texas
  • Harsh Chapadia Intern, Medical College Baroda

DOI:

https://doi.org/10.18203/2320-6012.ijrms20150814

Keywords:

Metabolic syndrome, Subclinical hypothyroidism, Euthyroid, Overt hypothyroid

Abstract

Background: Obesity, insulin resistance, physical inactivity, advanced age and hormonal disturbances have been suggested to be the underlying risk factors for the development of metabolic syndrome. Thyroid dysfunction can cause obesity, and can in turn lead to metabolic syndrome and can also be a cause of lipid abnormalities. Hence we tried to study the effect of thyroid function on the components of metabolic syndrome.

Methods: Blood pressure, waist circumferences, HDL cholesterol and triglycerides were measured in all patients. TSH was measured and on its basis patients were divided in three groups: euthyroid, hypothyroid and subclinical hypothyroid.

Results: There were 28 females and 22 males. Mean BMI was 31.51±5.21 kg/m2. The mean systolic blood pressure was 139.04±26.67 mm Hg and the diastolic pressure was 88.32±14.95 mm Hg. Mean waist circumference was 102±10.1 cm & mean waist: hip ratio was 0.97±0.094. HDL <50 in males and <40 in females in Euthyroid showed statistical significance (p value 0.05). Other components did not gain a statically significance. Comparing gender wise Subclinical hypothyroidism patients with Euthyroid patients, females having subclinical hypothyroidism are more likely to have metabolic syndrome (p value =0.03). This is not so in case of males.

Conclusions: Female patients having subclinical hypothyroidism have higher chances of have metabolic syndrome as compared to males. Euthyroid patients with metabolic syndrome had low cholesterol. Other components of metabolic syndrome had no statically significance with thyroid function.

 

References

Church TS. Metabolic Syndrome and Diabetes, Alone and in Combination, as predictors of cardiovascular disease mortality among Men. Diabetes Care. 2009;32(7):1289-94.

Roos A, Bakker S JL, Links T P, Gans R OB, and Wolffenbuttel B HR. Thyroid function is associated with components of metabolic syndrome. JCEM. 2006;92(2):491-6.

Grundy S M. Diagnosis and Management of the Metabolic Syndrome; An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. 2005;112:2735-52.

Mohan V, Deepa M, Farooq S, Datta M, Deepa R: Prevalence, Awareness and Control of Hypertension in Chennai – The Chennai Urban Rural Epidemiology Study (CURES – 52). JAPI. 2007;55:326-32.

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Published

2017-01-14

How to Cite

Shah, Y., Vadher, A., Reddy, K., & Chapadia, H. (2017). Does thyroid function have any relation with components of metabolic syndrome?. International Journal of Research in Medical Sciences, 3(10), 2682–2685. https://doi.org/10.18203/2320-6012.ijrms20150814

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Section

Original Research Articles