Organophosphorous intoxication and hyperthyroidism
DOI:
https://doi.org/10.18203/2320-6012.ijrms20150841Keywords:
Organophosphorus intoxication, Hyperthyroidism, Atropinisation, TachyarrhythmiaAbstract
It is well established that transient thyroid dysfunction can occur in many non-thyroid illness. But abnormal thyroid function test in the range of hyperthyroidism is not reported many a times. Here we present two cases of chlorpyrifos intoxication presenting with hyperthyroidism and its implications in the management of the patient in acute illness.
Role of atropine in antagonizing muscarinic effects of organophosphorus intoxication is well documented. Interplay between atropine, hyperthyroid state and tachycardia discussed.
Metrics
References
Tseng FY, Chen CS. Thyroid function tests in acute drug intoxication. J Formos Med Assoc. 1992;91 Suppl 1:S68-73.
Yuan YD, Seak CJ, Lin CC, Lin LJ. Thyroid storm precipitated by organophosphate intoxication. Am J Emerg Med. 2007;25(7):861.e1-3.
Amenta F, Caporuscio D, Ferrante F, Porcelli F, Zomparelli M. Cholinergic nerves in the thyroid gland. Cell Tissue Res. 1978;195(2):367-70.
Van Sande J, Dumont JE, Melander A, Sundler F. Presence and influence of cholinergic nerves in the human thyroid. J Clin Endocrinol Metab. 1980;51(3):500-2.
Eddleston M, Dawson A, Karalliedde L, et al. Early management after self-poisoning with an organophosphorus or carbamate pesticide – a treatment protocol for junior doctors. Critical Care. 2004;8(6):R391-R397.
Lacasaña M, López-Flores I, Rodríguez-Barranco M, Aguilar-Garduño C, Blanco-Muñoz J, Pérez-Méndez O, et al. Interaction between organophosphate pesticide exposure and PON1 activity on thyroid function. Toxicol Appl Pharmacol. 2010;249(1):16-24.