Malnutrition and central retinal vein occlusion in a young man
Keywords:Folate deficiency, Malnutrition
Can vitamin B12 and folate deficiency cause central retinal vein occlusion? We conducted a literature search to find out whether nutritional deficiency of vitamin B12 and folate can lead to impaired vision. The patient in the article reported in Ophthalmology, department of MMIMSR, Haryana, India, with complain of gradual painless visual loss over six weeks. He was found to have unilateral central retinal vein occlusion with significant anemia and vitamin B12 and folate deficiency. Vitamin B12 and folate deficiency can lead to elevated levels of homocysteine. We found a large amount of published data relating central retinal vein occlusion to elevated homocysteine levels, but there was a lack of conclusive evidence for this association Patients should be asked about their dietary history where a thrombotic event is suspected or confirmed.
Klein R, Klein BE, Moss SE, Meuer SM. The epidemiology of retinal vein occlusion: the Beaver Dam Eye Study. Trans Am Ophthalmol Soc. 2000;98:133.
David R, Zangwill L, Badarna M, Yassur Y. Epidemiology of retinal vein occlusion and its association with glaucoma and increased intraocular pressure. Ophthalmologica. 1988;197:69.
Clarkson JG. Central retinal vein occlusion. In Retina. 3rd edition. Edited by Schachat AP. St. Louis, MO: Mosby; 2001:1368.
Foulds WS. Blood is thicker than water. Some haemorheological aspects of ocular disease. Eye. 1987;1:343.
Hughes M, Leach M. Dietary Folate deficiency and bilateral retinal haemorrhages. Lancet. 2006;368(9553):2155.