A comparative study on the lipid peroxidation and total antioxidant status in patients with and without varicose veins
DOI:
https://doi.org/10.18203/2320-6012.ijrms20162930Keywords:
Varicose veins, Melondialdehyde, Glutathione peroxidase, Total antioxidant capacityAbstract
Background: The prevalence of varicose veins was increasing with increasing age but a deviance from the normal prevalence of the female patients. The patho- physiology has yet not been clearly delineated but the role of certain enzymes leading to oxidative stress has been implicated in the causation of this disease. Therefore, the present study was conducted to compare the lipid peroxidation and total antioxidant status in the patients with and without varicose veins.
Methods: This study was performed after the institutional ethical clearance and informed consent from all the participants. Patients who were admitted for the surgery of inguinal Hernia were taken as controls. The blood was obtained and its serum was used for the estimation of MDA, GPx, and total antioxidant status using commercially available kit, according to the manufacturer’s guidelines in the central research laboratory of the institute. The data was represented as Mean±S.D. and compared using students‘t’ test and a p value of <0.05 was considered the level of significance.
Results: The Serum estimations of MDA, GPX and TAC on comparison to Normal Individuals did not show any statistical significance (p>0.05).
Conclusions: The levels of MDA, GPX and TAC were at the upper limit of the normal ranges in patients of Varicose veins indicating that more on antioxidants as a measure of global stress index in varicose veins are needed to be performed in the future with different Antioxidants and Advent of investigative modalities for the same.
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References
Glowinski J, Glowinski S; Generation of reactive oxygen metabolites by the varicose vein wall: Eur J Vasc Endovasc Surg. 2002;23(6):550-5.
Condezo-Hoyos L. A plasma oxidative stress global index in early stages of chronic venous insufficiency: J Vasc Surg. 2003;57:205-13.
Hesham A. Can oxidant, antioxidant, and adhesion molecules levels predict prognosis in patients with varicose veins? Egyptian Journal of Surgery. 2003;22:23-30.
Kozka M, Krzysciak W, Pietrzycka A, Stepniewski M. Obesity and its influence on Reactive Oxygen Species (ROS) in the blood of patients with Varicose Veins of the lower limbs. Rzegl Lek. 2009;66(5):213-7.
Karatepe O, Unal O, Ugurlucan M, Kemik A, Karahan S, Aksoy M, et al. The Impact of Valvular Oxidative stress on the development of venous stasis ulcer valvular oxidative stress and venous ulcers. Angiology. 2010;61(3):283-8.
Krzysciak W, Kowalska J, Kozka M, Papiez MA, Kwiatek WM. Iron content (PIXE) in competent and incompetent veins is related to the vein wall morphology and tissue antioxidant enzymes. Bioelectrochemistry. 2012;87:114-23.
Schultz-Ehrenburg U, Weindorf N, Von Uslar D. Prospektive epidemiologische Studie uber die Entstehungsweise der Krampfadren bei Kindern und Jungendlichen (Bochumer Studie I und II). Phlebol Proktol. 1989;18:3-11.
Jantet G. The RELIEF Study group: Chronic Venous Insuffeciency: Worldwide results of the RELIEF Study. Angiology. 2001;53:245-56.
Fowkes FGR, Evans CJ, Lee AJ. Prevalence and risk factors of Chronic Venous Insuffeciency. Angiology. 2001;52(suppl 1):s5-s15.
Danielsson G, Eklof B, Grandinetti A. The influence of obesity on Chro nic Venous Disease. J Vasc Endovasc Surg. 2002;36:271-6.
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