Comparative evaluation of efficiency of HbA1C, fasting & post prandial blood glucose levels, in the diagnosis of type-2 diabetes mellitus and its prognostic outcome

Mirza Asif Baig


Background: HbA1C a marker of chronic hyperglycemia, is associated with diabetes and its complications and has been recommended as a diagnostic test. It is an indicator of average blood glucose concentration over the period of 2-3 months. The main objective of this study was to compare the efficiency of HbA1C, fasting & post prandial blood glucose levels, in the diagnosis of type- 2 diabetes mellitus.

Methods: This study was conducted in a tertiary care referral hospital. Total 500 subjects included. 

Results: The study and control group were almost of the similar ages. FBS & 2 hour PP of control groups are 95.5 ± 9.8 & 168.45 ± 22.8 (mg/dl) respectively & that of type 2DM is 198.5 ± 25.6 & 295.8 ± 32.6 respectively. The HbA1C % of all the 30 cases of DR & all the cases with micro-albuminuria was >7.5%.  

Conclusions: HbA1C can be used effectively for the diagnosis of type 2 DM & it can be used for predicting the complications of type 2 DM. It shows a direct & linear correlation with the diabetic retinopathy and micro-albuminuria. It is very safe to say that HbA1C is better parameter than FBS & 2 hour PP BS level in diagnosing & predicting the complications of diabetes.



Type-2 diabetes mellitus, Fasting blood glucose, HbA1C, Diabetic retinopathy, Microalbuminuria

Full Text:



Abdulfatai B, Olusegun A. Type 2 diabetes mellitus: a review of current trends. Oman Med J. 2012 Jul;27(4):269-73.

Qazi Najeeb, Ruqaya Aziz, Sajad Hamid. To evaluate the levels of glycated hemoglobin, serum calcium, magnesium, phosphate, uric acid and microalbuminuria in patients with newly diagnosed type 2 diabetes mellitus. Int J Res Med Sci. 2014 Nov;2(4):1462-5.

The International Expert committee. International Expert Committee report on the role of A1C assay in the diagnosis of diabetes. Diabetes Care. 2009;32:1327-34.

New American Diabetes Association (ADA) 2015 Guidelines. Standards of medical care in diabetes - 2015. Diabetes Care. 2015;38(Suppl 1):S1-93.

Fauci, Braunwald, Kasper, Hauser, Longo, Jameson. Harrison’s principles of internal medicine. In: Fauci, Braunwald, Kasper, Hauser, Longo, Jameson, eds. A Book. 17th ed. New York: McGraw-Hill; 2008.

Robert J. McCarter, James M. Hempe. Biological variation in HbA1C predicts risk of retinopathy and nephropathy in type 1 diabetes. Diabetes Care. 2004;27:1259-64.

Ramin Ahmadi, Haq Nawaz. Utility of HbA1C levels for diabetes case finding in hospitalized patients with hyperglycemia. AMJ Diabetic Care. 2003;26:1064-8.

Scragg R, Sowers M, Bell C. Serum 25-hydroxyvitamin D, diabetes, and ethnicity in the Third National Health and Nutrition Examination Survey. Diabetes Care. 2004;27:2813-8.

Borissova AM, Tankova T. The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients. Int J Clin Pract. 2003;57:258-61.

American Diabetes Association. Diagnosis & classification of DM. Diabetes Care. 2010;33(Suppl 1):S62-9.

WHO. Use of glycated haemoglobin (HbA1C) in the diagnosis of diabetes mellitus. Abbreviated Report of a WHO Consultation No. WHO/NMH/CHP/CPM/11.1. Geneva: World Health Organization; 2011: 1-25.