DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20151395

Seroprevalence of hepatitis B antigenemia among dental students in a private South Indian dental institution

Bhuvan Nagpal, Usha Hegde, Madhuri Kulkarni

Abstract


Background: Hepatitis B is the most important infectious occupational disease for the dental health care workers (DHCWs). DHCWs frequently come in contact with blood and saliva and hence are at risk for Hepatitis B virus (HBV) exposure. Studies indicate that DHCWs, through occupational exposure, may have a 10 times greater risk of becoming a chronic hepatitis B carrier than the average citizen.

The study was conducted to estimate the seroprevalence of HBV infection among dental students enrolled at a private dental institution in Mysuru, Karnataka, India.

Methods: A cross sectional seroprevalencestudy was conducted which included dental students who were enrolled in the dental institution. Data were collected by administering a standard questionnaire to every student regarding their personal health information. Their blood samples were collected and tested by Enzyme Linked Immunosorbent assay (ELISA) for Hepatitis B surface antigen.

Results: 352 dental students who gave consent were screened out of a total of 453 dental students. Out of 352 students, 163 (46%) were vaccinated and 189 (54%) were non-vaccinated. All the dental students were found to be seronegative for HBV infection.

Conclusions: Though a low rate of HBV infection was observed among dental students, a significant number of dental students were non-vaccinated which suggests a need for proactive implementation of HBV vaccination programme.

 


Keywords


Dental health care workers, Hepatitis B, Hepatitis B surface antigen, South India, Vaccination

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References


Previsani N, Lavanchy D. World Health Organization. Hepatitis B (WHO/CDS/ CSR/LYO/2002.2). 2002

Prüss-Üstün A, Rapiti E, Hutin Y. Estimation of the global burden of disease from sharps injuries to health-care workers. Am J Ind Med. 2005;48:482-90.

Werner BG, Grady GF. Accidental hepatitis-B-surface-antigen-positive inoculations: Use of e antigen to estimate infectivity. Ann Intern Med. 1982;97:367-369.

Lauer JL, VanDrunen NA, Washburn JW, Balfour HH Jr. Transmission of hepatitis B virus in clinical laboratory areas. J Infect Dis. 1979;140:513-516.

Gillen M, McNary J, Lewis J, Davis M, Boyd A, Scheiller M et al. Sharps related injuries in California healthcare facilities: pilot study results from the Sharps Injury Surveillance Registry. Infection Control and Hospital Epidemiology. 2003;24:113-21.

O’Connell T and Hayes B. Occupational sharps injuries in a Dublin teaching hospital. Iranian Medical Journal. 2003;96:143-145.

Shiao J, Guo L, Mclaws ML. Estimation of the risk of bloodborne pathogens to health care workers after a needlestick injuries in Taiwan. American Journal of Infection Control. 2002;30:15-20.

US Public Health Service. Updated U.S. Public Health Service Guidelines for the Occupational Exposures of HBV, HCV, and HIV and Recommendations for Post-exposure Prophylaxis. MMWR Recomm Rep. 2001;50:1-52.

Lamster IB and Ahlo JK. Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases. Annals of the New York Academy of Sciences. 2007;1098:216–29.

World Health Organization. (WHO). Hepatitis B. 2012. Available at http://www.who.int/mediacentre/factsheets/fs204/en/index.html. Accesed 20 August 2015.

World Health Organization (2012). Hepatitis B. World Health Organization Fact Sheet 204 (Revised August 2008). Available at http://who.int/inf-fs/en/fact204.html. Accesed 20 August 2015.

Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat. 2004;11(2):97-107.

Lok AS. Chronic hepatitis B. N Engl J Med. 2002;346(22):1682-3.

Goldstein ST, Zhou F, Hadler SC, et al. A mathematical model to estimate global hepatitis B disease burden and vaccination impact. Int J Epidemiol. 2005;34:1329-339.

Te HS, Jensen DM. Epidemiology of hepatitis B and C viruses: a global overview. Clin Liver Dis. 2010;14:1-21.

Puri P, Srivastava S. Lower chronic hepatitis B in South Asia despite all odds: Bucking the trend of other infectious diseases. Trop Gastroenterol. 2012;33(2):89–94.

Dutta S. An overview of molecular epidemiology of hepatitis B virus (HBV) in India. Virol J. 2008;5:156.

World Health Organization, 2012. Introducing Hepatitis B Vaccine in Universal Immunization Programe in India. A Brief Scenario. Available at http://www.whoindia.org/en/section6/section8.htm.

Accesed 20 August 2015.

Abraham P. Viral Hepatitis in India. Clin Lab Med. 2012;32(2):159-74.

Thyagarajan SP, Jayaram S, Mohanavalli B. Prevalence of HBV in general population in India. In: Sarin SK, Singal AK, eds. Hepatitis B in India: problems and prevention. New Delhi: CBS;1996. pp.5-16.

Murhekar MV, Murhekar KM, Sehgal SC. Alarming prevalence of hepatitis-B infection among the Jarawas—a primitive Negrito tribe of Andaman and Nicobar Islands, India. J Viral Hepat. 2003;10(3):232–3.

Murhekar MV, Murhekar KM, Das D, et al. Prevalence of hepatitis B infection among the primitive tribes of Andaman and Nicobar Islands. Indian J Med Res. 2000;111:199-203.

Biswas D, Borkakoty BJ, Mahanta J, et al. Hyperendemic foci of hepatitis B infection in Arunachal Pradesh, India. J Assoc Physicians India. 2007;55:701-704.

Saha MK, Chakrabarti S, Panda S, et al. Prevalence of HCV and HBV infection amongst HIV seropositive intravenous drug users and their non-injecting wives in Manipur, India. Indian J Med Res. 2000;111:37-9.

Zaidi AKM, Awasthi S, deSilva HJ. Burden of infectious diseases in South Asia. BMJ. 2004;328:811-5.

Singhal V, Bora D, Singh S. Prevalence of Hepatitis B Virus Infection in Healthcare Workers of a Tertiary Care Centre in India and their Vaccination Status. J Vaccines Vaccin. 2011;2:118.

Sukriti, Pati NT, Sethi A, Agrawal K, Agrawal K, et al. Low levels of awareness, vaccine coverage, and the need for boosters among health care workers in tertiary care hospitals in India. J GastroenterolHepatol. 2008;23:1710-5.

Kumar KKA, Baghal PK, Shukla CB, Jain MK Prevalence of hepatitis B surface antigen (HBsAg) among Health Care Workers. Indian J Comm Med. 2000;25:93-6.

Martin DB, Jannausch M, Skenedzel LP. The prevalence of hepatitis B in employees of small, rural hospitals implications for vaccine administration. Infect Control. 1986;7:64-6.

Ajayi AO, Komolafe AO, Ajumobi K. Seroprevalence of Hepatitis B antigenemia among health care workers in a Nigerian tertiary health institution. Nigerian Journal of Clinical Practice. 2007;10(4):287-9.

Olubuyide IO, Ola SO, Aliyu B, Dosumu OO, Arotiba JT, et al. Prevalence and epidemiological characteristics of hepatitis B and C infections among doctors and dentists in Nigeria. East Afr Med J. 1997;74:357-61.

Simard EP, Miller JT, George PA, Wasley A, Alter MJ, et al. Hepatitis B Vaccination Coverage Levels among Healthcare Workers in the United States, 2002-2003. Infect Control Hosp Epidemiol. 2007;28:783-90.

Dannetun E, Tegnell A, Torner A, Gieseche J Coverage of hepatitis B vaccination in Swedish healthcare workers. J Hospital Inf. 2006;63:201-4.

Nagao Y, Matsuoka H, Kawaguchi T, Ide T, Sata M HBV and HCV infection in Japanese dental care workers. Intern J Mol Med. 2008;21:791-9.

Martins AM, Barreto SM. Hepatitis B vaccination among dentists surgeons. Revista de SaudePublica. 2003;37:333-8.

Ottoni CM, Penna FJ, Oliveira CG, Souza CJ. Prevalence of serologic markers of hepatitis B in dentistry students and dentists in Belo Horizonte, Brazil. 1995;118(2):108-14.