The prevalence of anti-thyroid peroxidase antibodies in subclinica and clinical hypothyroid patients

Jayashankar C.A.; Avinash S.; Shashidharan B.; Vijaya Sarathi; Shruthi K.R.; Nikethan D.; Harshavardhan J.

doi:10.18203/2320-6012.ijrms20151399

Authors

Jayashankar C.A. Associate Professor, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Avinash S. Senior Resident, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Shashidharan B. Professor, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Vijaya Sarathi Assistant Professor, Department of Endocrinology, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Shruthi K.R. Postgraduate student, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Nikethan D. Postgraduate student, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka
Harshavardhan J. Postgraduate student, Department of General Medicine, Vydehi Institute of Medical sciences and research centre, Whitefield, Bangalore Karnataka

DOI:

https://doi.org/10.18203/2320-6012.ijrms20151399

Keywords:

Clinical hypothyroidism, Subclinical hypothyroidism, Anti-TPO antibodies

Abstract

Background: Subclinical hypothyroidism is a state of mild thyroid failure and is essentially a laboratory diagnosis with elevated serum thyroid stimulating hormone (TSH) and a normal free thyroxine (FT4) concentration. The main objective of study is to evaluate the prevalence of anti-thyroid peroxidise (anti-TPO) antibodies among patients with clinical and subclinical hypothyroidism.

Methods: A prospective study was conducted involving 50 patients with biochemical evidence of hypothyroidism. Subclinical hypothyroidism was defined as thyroid stimulating hormone (TSH) >5.0 µIU/ml with normal FT4 and clinical hypothyroidism as free thyroxine (FT4) and high TSH. A detailed history, clinical examination, and investigations comprising of complete haemogram, fasting plasma glucose, fasting FT4, TSH, anti-TPO antibodies and lipid profile were done for all the patients.

Results: Out of 50 cases, 28 subjects had clinical hypothyroidism (25 females and 3 males) and 22 had subclinical hypothyroidism (14 females and 8males). Among the 50 subjects with clinical and subclinical hypothyroidism, 33 were anti-TPO positive. The corresponding percentage of anti-TPO positivity noted in the clinical hypothyroidism and subclinical hypothyroidism groups were 80 % and 50% respectively.

Conclusions: Serum TSH and anti-TPO analyses are essential in determining the etiology of hypothyroidism and risk of progression to overt hypothyroidism in patients with subclinical.

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