DOI: http://dx.doi.org/10.18203/2320-6012.ijrms20151411

Comparing hypertonic saline and xylometazoline in allergic rhinitis

O. N. Sinha, Monika Deswal

Abstract


Background: Allergic rhinitis (AR) affects productivity, quality of life and performance at work. Pharmacological agents are widely used and nasal irrigation using hypertonic saline is underused.

Methods: All consecutive patients presenting at the outpatient clinic with complaints of AR at Santosh Medical College Hospital from August 1, 2014 to August 31, 2015 were included in the study. Patients were randomly assigned to either xylometazoline nasal drops (0.1%, three times a day, brand Otrivin) or hypertonic seawater saline (2.2%, three times a day, brand Physiomer). They were followed for a period of 2 months. Symptom change was assessed at the start of the treatment and at the end using the Nasal Index Score (NIS), which comprised of grading blocked nose, runny nose, sneezing and eye itching on a 4-point severity scale.

Results: 85 patients were included in the final analysis. On the NIS, patients receiving hypertonic nasal drops showed a decrease in mean score by 0.7, 0.5, 0.7 and 0.7 for blocked nose, runny nose, sneezing and eye irritation respectively, all of which were statistically significant. Additionally, more side effects like bloody nasal discharge, respiratory infections and headache were seen with xylometazoline nasal drops.

Conclusion: Our findings suggest that using hypertonic nasal drops can reduce the dependence on pharmacological agents like xylometazoline, improve symptoms and quality of life with fewer adverse reactions.


Keywords


Allergic rhinitis, Hypertonic nasal drops

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References


Hermelingmeier KE, Weber RK, Hellmich M, Heubach CP, Mösges R. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis. Am J Rhinol Allergy. 2012;26(5):e119-25.

Tabary O, Muselet C, Yvin JC, Halley-Vanhove B, Puchelle E, Jacquot J. Physiomer reduces the chemokine interleukin-8 production by activated human respiratory epithelial cells. Eur Respir J. 2001;18(4):661-6.

Papsin B, McTavish A. Saline nasal irrigation: Its role as an adjunct treatment. Can Fam Physician. 2003;49:168-73.

Aberg N, Hesselmar B, Aberg B. Increase of asthma, allergic rhinitis, and eczema in Swedish school children between 1979 and 1991. Clin Exp Allergy. 1995;25:815-9.

Howarth PH. The cellular basis for al- lergic rhinitis. Allergy. 1995;50(Suppl):6-10.

Brogden RN, McTavish D. Budes- onide. An updated review of its phar- macological properties, and therapeu- tic efficacy in asthma and rhinitis. Drugs. 1992;44:375-407.

Fokkens WJ. Nasal corticosteroids, first choice in moderate to severe allergic rhinitis. What prevents general practitioners from using them? Allergy 2003;8:724-6.

Garavello W, Romagnoli M, Sordo L, Gaini RM, Di Berardino C, Angrisano A. Hypersaline nasal irrigation in children with symptomatic seasonal allergic rhinitis: a randomized study. Pediatr Allergy Immunol. 2003;14(2):140-3.

Bousquet PJ, Cropet C, Klossek JM, Allaf B, Neukirch F, Bousquet J. Effect of smoking on symptoms of allergic rhinitis. Ann Allergy Asthma Immunol. 2009;103(3):195-200.

Hur K, Liang J, Lin SY. The role of secondhand smoke in allergic rhinitis: a systematic review. Int Forum Allergy Rhinol. 2014;4(2):110-6.

Saulyte J, Regueira C, Montes-Martínez A, Khudyakov P, Takkouche B. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis. PLoS Med. 2014;11(3):e1001611.

Tabary O, Muselet C, Yvin JC, Halley-Vanhove B, Puchelle E, Jacquot J. Physi- omer reduces the chemokine interleukin-8 production by activated human res- piratory epithelial cells. Eur Respir J. 2001;18(4):661-6.

Hartog B, van Benthem PP, Prins LC, Hordijk GJ. Efficacy of sinus irrigation versus sinus irrigation followed by functional endoscopic sinus surgery. Ann Otol Rhinol Laryngol. 1997;106(9):759-66.

Brown CL, Graham SM. Nasal irrigations: good or bad? Curr Opin Otolaryngol Head Neck Surg. 2004;12(1):9-13.