Prevalence of dyslipidemia in patients with type 2 diabetes mellitus: a hospital based study in Kishanganj, India

Manisha Mandal, Rina Kumari, Arati Mukherjee


Background: A major risk factors for cardiovascular disease in type 2 diabetes mellitus (T2DM) is dyslipidemia characterized by high plasma triglyceride (TG), low HDL and increased LDL. Early detection of dyslipidemia in T2DM can help in the management and prevention of cardiovascular disease. The present study is based on the detection of anomalous lipid profile in T2DM patients.

Methods: A total of 35 T2DM patients with fasting blood glucose (FBG) > 110 mg/dL, and 32 subjects with FBG (70-110 mg/dL) were considered as controls. Serum samples were assayed for determination of the levels of total Cholesterol (TC), HDL, LDL, TG, and VLDL. Variables were compared between T2DM subjects and controls, with statistical significance at p ≤0.05.

Results: The prevalence of dyslipidemia was 12 (34.29%) and 9 (25.71%) with abnormal lipids levels of TC and TG respectively whereas 11 (31.43%), 12 (34.29), and 9 (25.71%) were found with lipoprotein abnormalities of HDL, LDL and VLDL respectively in T2DM subjects either singly or in combination. The serum parameters TC, TG, HDL, LDL, and VLDL were significantly correlated to FBG levels in both diabetic and non-diabetic subjects. The variables were also significantly associated among each other in T2DM patients.

Conclusion: The present study provides evidence to suggest that lipid variables are associated with each other in T2DM patients among the population of Kishanganj, India.



Lipid profile, Type 2 diabetes mellitus, Dyslipidemia

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Gadi R, Samaha FF. Dyslipidemia in Type 2 diabetes mellitus. Curr Diabet Reports. 2007;7:228-34.

Atiba AS, Oparinde DP, Babatunde OA, Niran-Atiba TA, Jimoh AK. Liver enzymes and lipid profile among type 2 diabetic patients in Osogbo, Nigeria. Greener J Med Sci. 2013;3(5):174-8.

Chehade JM, Gladysz M, Mooradian AD. Dyslipidemia in type 2 diabetes: prevalence, pathophysiology, and management. Drugs. 2013;73(4):327-39.

Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrin Metab. 2009;5:150-9.

Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Rev Endocrinol. 2009;5:150-9.

Allain CC, Poon LS, Chan CGS, Richmond W, Fu PC. Enzymatic determination of total serum cholesterol. Clin Chem. 1974;20(4):470-5.

Bucolo G, David H. Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem. 1973;19(5):476-82.

Naito HK. HDL Cholesterol. In: Kaplan A. ed. Clinical Chemistry: Theory, Analysis and Correlation. St Louis, Toronto, Princeton: The CV Mosby Co. 1984:1207-1213, 437.

Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clini Chem. 1972;18(6):499-502.

Cheesbrough M. District Laboratory practice in tropical countries. Part I. Cambridge, UK: Cambridge University Press. 2005:343-346.

Goldberg AC. Dyslipidemia, 2015. Available at Accessed 7 October 2015.

Tagoe DNA, Amo-Kodieh P. Type 2 diabetes mellitus influences lipid profile of diabetic patients. Ann Biol Res. 2013;4(6):88-92.

Hidron AI, Edwards JR, Patel J, Horan TC, Sievert DM, Pollock DA. NHSN annual update: Antimicrobial-resistant pathogens associated with healthcare-associated infections: annual summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2006-2007. Infect Control Hosp Epidemiol. 2008;29(11):996-1011.

Uttra KM, Devrajani BR, Shah SZA, Devrajani T, Das T, Raza S, et al. Lipid Profile of Patients with Diabetes mellitus. World Appl Sci. 2011;J12(9):1382-4.

Dixit AK, Dey R, Suresh A, Chaudhuri S, Panda AK, Mitra A, et al. The prevalence of dyslipidemia in patients with diabetes mellitus of ayurveda Hospital. J Diabet Metabol Disorders. 2014;13:58.

Gordon L, Ragoobirsingh D, St Morrison EYA, Choo-Kang E, McGrowder D, Martorell E. Lipid profile of type 2 diabetic and hypertensive patients in the Jamaican population. J Lab Physicians. 2010;2(1):25-30.

Firdous S, Khan MZ. Comparison of patterns of lipid profile in type-2 diabetics and nonraised diabetics. Ann King Edward Med Coll. 2007;3(1):84-7.

Vinter-Repalust N, Jurkomo L, Katie M, Simunovic R, Petric D. The disease duration, patient compliance and the presence of complica¬tions in diabetic patients. Acta Med Croatica. 2007;61(1):57-62.

Fredrickson DS, Lees RS. A system for phenotyping hyperlipoproteinemia. Circulation. 1965;31:321-7.

Gen Yoshino. Dyslipidemia in diabetes mellitus. Diabetes Res Clin Practice. 1996;33(1):1-14.

Packard C, Nunn A, Hobbs R. High density lipoprotein: guardian of the vascular system. Inter J Clin Pract. 2002;56:761-71.

Solano MP, Goldberg RB. Lipid Management in Type 2 Diabetes. Clin Diabet. 2006;24(1):27-32.

Mahato RV, Gyawali P, Raut PP, Regmi P, Singh PK, Pandey DR, et al. Association between glycaemic control and serum lipid profile in type 2 diabetic patients: glycated haemoglobin as a dual biomarker. Biomed Res. 2011;22(3):375-80.

McNamara JR, Jenner JL, Li Z, Wilson PW, Schaefer EJ. Change in LDL particle size is associated with change in plasma triglyceride concentration. Arterioscler Thromb Vasc Biol. 1992;12:1284-90.

Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabet Care. 2004;27:1496-504.

Samatha P, Venkateswarlu M, Siva Prabodh V. Lipid profile levels in type 2 diabetes mellitus from tribal population of Adilabad in Andhra Pradesh, India. J Clin Diagnostic Res. 2012;6(4):590-2.

Hopkins GJ, Barter PJ: Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins. J Lipid Res. 1986;27:1265-77.

Pandya H, Lakhani JD, Dadhania J, Trivedi A. The prevalence and pattern of dyslipidemia among type 2 diabetic patients at rural based hospital in Gujarat, India. J Clin Prac. 2012;22(12):36-44.