Study of bone marrow: dyserythropoiesis for etiological evaluation of anemia

Jignesh K. Parmar; Shamim Sheikh

doi:10.18203/2320-6012.ijrms20151431

Authors

Jignesh K. Parmar Department of Pathology, Shri M.P. Shah Govt. Medical College, Jamnagar, Gujarat
Shamim Sheikh Department of Pathology, Shri M.P. Shah Govt. Medical College, Jamnagar, Gujarat

DOI:

https://doi.org/10.18203/2320-6012.ijrms20151431

Keywords:

Dyserythropoiesis, Bone marrow aspiration and examination

Abstract

Background: Bone Marrow Aspiration plays a major role in the diagnosis of various hematolgical disorders which are very frequent in various age groups. The aim of this study was to analyze the causes of haematological disorders, and to interpret the bone marrow aspiration findings with various dyserythropoietic changes in it.

Methods: This was a study carried out in the department of Pathology of Shri M P Shah Govt. Medical college over a period of two years from June 2008 to June 2010. Bone marrow examination of 100 cases of suspected haematological disorders was carried out. All details of the patients were the recorded in the department of pathology.

Results: Out of 100 cases of bone marrow aspiration, erythroid hyperplasia and megaloblastic changes were commonest findings and Megaloblastic anemia was most common diagnosis given on bone marrow examination. Other dyserythropoietic changes were erythroidhypoplasia, micronormoblasts, dimorphic erythropoiesis, megaloblastoid changes and other like – cytoplasmic bleb, multinucleation,nuclear bridging.

Conclusions: The sincere blood film examination and keen morphological evaluation of erythroid series for dyserythropiesis and leukopoesis and megakaryopiesis in bone marrow aspiration smear - supported with other investigation can navigate to etiological factors of anaemia and other haematological disorders.

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References

Bashawri LA. Bone marrow examination. Indications and diagnostic value. Saudi Med J. 2002:23(2):191-6.

Brynes RK, Mckenna RW, Sundbeerg RD. Bone marrow aspiration and trephine biopsy: an approach to a thorough study. Am J Clin Pathol. 1978;70:753-9.

Lewis SM, Bain BJ, Bates I, Dacie and Lewis. Practical hematology, Churchill livingstone, 9th edition. 2001:101-4.

Rubin E, John L. Farber: Pathology. The blood and lymphoid organs.1988:1014.

Bansal D.Congenital dyserythropoietic anemia In :Agarwal M B: Hematology Today 2010:647.

Hardysty RM and Weathervall DJ. Blood and its disorders, Blackwell scientific Publication. 1974:1115.

Wintrobes. Examination of blood and bone marrow In: Sherrie L. Perkins editors Clinical Haematology. 10th ed. Maryland: Williams and Wilkins. 1999:23- 32.

Kibria SG, Islam MDU, ASMJ Chowdhury ASMJ, Ali MY, Haque MR, Mustanzid SM, Ali SY. Prevalence 0f Hematological Disorder: A Bone Marrow Study of 177 Cases In A Private Hospital At Faridpur , Faridpur Med. Coll. J. 2010;5:11-3.

Das KC. Editorial: Dyserythropoiesis-an objective evaluation. Indian J Pathol Bacteriol. 1973;16(3):1-11.

D’costa GF, Dua SR, Patil YV. A spectrum of paediatric bone marrow trephine biopsy- Bombay hospital journal. 2007:49(3):453-63.

Thiyagarajan P, Suresh TN, Anjanappa R, Harendra Kumar ML. Bone-marrow spectrum in a tertiary care hospital: Clinical indications, peripheral smear correlation and diagnostic value. Med J DY Patil Univ. 2015;8:490-4.

Tahlan A, Bansal C, Palta A, Chauhan S. Spectrum and analysis of bone marrow findings in anemic cases. Indian Journal of Medical Sciences. 2008;62(8):336-9.

Dhingra KK, Gupta P, Saroha V, Setia N, Khurana N, Singh T. Morphological findings in bone marrow biopsy and aspirate smears of visceral kala azar: A review. Indian J Pathol Microbiol. 2010;53:96-100.

Tripathi AK, Kalra P, Misra R, Kumar A, Gupta N. Study of Bone Marrow Abnormalities in Patients with HIV Disease. AK JAPI. 2005;53:105-10.