High resolution ultra sound and color Doppler in evaluation of thyroid nodule with fine needle aspiration cytology correlation

Suman Chaudhary, Anand Prakash Verma, Hemant K. Mishra


Background: Thyroid gland is the first to develop in fetal life and is largest of all the endocrine glands. It is superficial in location which helps in its excellent visualization of normal anatomy and pathologic condition by high resolution real time grey scale sonography. The purpose of this study was to evaluate the usage of grey scale ultrasound and color Doppler with FNAC correlation for differentiation of benign and malignant thyroid nodule.

Methods: This prospective study was carried out on sixteen patients who came to our department from period of 1 February to  31 march 2016.Grey scale ultrasound of neck  and Doppler followed by USG guided FNAC of thyroid swelling was done.

Results: Out of 16 cases, 3 were malignant, 10 were benign, and 3 were indeterminate. One case was diagnosed as benign lesion on sono which came out to be malignant on pathology as follicular carcinoma. The cases were presented as hypoechoic lesion with regular margins with peripheral and internal vascularity. Due to well defined margins it was diagnosed as benign adenoma but turned out to be malignant on pathology as follicular carcinoma. Colloid goiter was most common presentation on ultrasound and it showed wide spectrum of appearance, majority being nodular with anechoic echotexture.

Conclusions: High resolution grey scale ultra sound with color Doppler has emerged as initial modality of choice for evaluating the patient with thyroid enlargement.


Thyroid, Ultrasonography, Fine neddle aspiration cytology, Color Doppler

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Tamhane S, Gharib H. Thyroid nodules update in diagnosis and management. Clinical diabetes and endocrinology. 2015;1:11. DOI: 10.1186/s40842-015-0011-7

Salehi M, Nalaini F, Izadi B, Setayeshi K, Rezaei M, Naseri SN. Gray-Scale vs. Color Doppler Ultrasound in Cold Thyroid Nodules. Glob J Health Sci. 2015;7(3):147-52.

Nachiappan AC, Metwalli ZA, Hailey BS, Patel RA, Ostrowski ML, Wynne DM. The thyroid: review of imaging features and biopsy techniques with radiologic-pathologic correlation. Radio-graphics. 2014;34(2):276-93.

Moon WJ, Baek JH, Jung SL, Kim DW, Kim EK, Kim JY, et al. Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiol. 2011;12(1):1-14.

Lee YH, Kim DW, In HS, Park JS, Kim SH, Eom JW, et al. Differentiation between Benign and Malignant Solid Thyroid Nodules Using an US Classification System. Korean J Radiol. 2011;12(5): 559-67.

Bonavita JA, Mayo J, Babb J, Bennett G, Oweity T, Macari M, et al. Pattern recognition of benign nodules at ultrasound of the thyroid: which nodules can be left alone? AJR Am J Roentgenol. 2009;193(1):207-13.

Lyshchik A, Drozd V, Demidchik Y, Reiners C. Diagnosis of Thyroid Cancer in Children: Value of Gray-Scale and Power Doppler US. Radiology. 2005;235:604-13.

Ahuja A, Chick W, King W, Metreweli C. Clinical significance of the comet-tail artifact in thyroid ultrasound. J Clin Ultrasound. 1996;24(3):129-33.

Takashima S, Fukuda H, Nomura N, Kishimoto H, Kim T, Kobayashi T. Thyroid nodules: Re-evaluation with ultrasound. Journal of Clinical Ultrasound. 1995. DOI: 10.1002/jcu.1870230306.

Mehta N. Sonographic appearance of solitary thyroid nodule. Ind J. Radiol. Imag. 1994;4(4);207-11.

Frates MC, Marqusee E, Benson CB, Alexander EK. Subacute Granulomatous (de Quervain) Thyroiditis. Grayscale and Color Doppler Sonographic Characteristics. JUM. 2013;32(3):505-11.