Comparative evaluation of propofol-ketamine and propofol-fentanyl for minor surgical procedures

Dharamsing Pawar, Pankaj Bhople, Sushma Pandey, Sonali Khobragade


Background: Aim of the present study was to compare the clinical efficacy of combination of propofol-ketamine and propofol-fentanyl in terms of haemodynamic variables, recovery profile and side effects.

Methods: The study enrolling 120 patients of (age 20-50 years) ASA grade I & II were randomly allocated in two groups of sixty each. They were undergoing short surgical procedures lasting up to 20 minutes. Group I received injection ketamine 0.5 mg/kg over 2 minutes followed by injection propofol at rate of 1 ml over 3 seconds till the end point of induction (till loss of consciousness and loss of eye lash reflex). Group II received injection fentanyl 1.5 µg/kg followed by 1 ml propofol till the end point of induction and maintenance of anesthesia. Hemodynamic variables were recorded pre, intra and postoperatively at regular intervals. Recovery and side effects was also assessed. The results were tabulated and analyzed statistically.

Results: Patients in both the groups produce minor haemodynamic changes and did not differ significantly. The recovery time was longer in group I as compare to group II. We found no complications of serious type except vomiting and nausea in group II. Discharge criteria were significantly earlier in group I than group II.

Conclusions: Both propofol-ketamine and propofol-fentanyl was useful for short surgical procedures but propofol-ketamine group offers more advantage.



Propofol, Ketamine, Fentanyl, Hemodynamic variables, Recovery time

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