Role of immunohistochemistry in the differential diagnosis of malignant small round cell tumor: a study of 38 cases

Amita Patel, Mubin Patel, Vasudha Bhagat, Kinnari Naik


Background: : Immunohistochemistry play a very important role in modern surgical pathology especially for identification of tumors lacking the evidence of lineage differentiation on the basis of routine Hematoxylin and Eosin (H&E) stain alone. More than 90% of the tumor with diagnostic difficulties by routine H & E stain could be very well classified by using IHC. The aim of present study is to classify and identify MSRCT.

Methods: The study was carried out in Department of Pathology, Government Medical College in a period from August 2008 to November 2011. Total 38 cases of MSRCT are selected for Immunohistochemical staining (IHC) and they are classified and categorized accordingly after IHC.

Results: Out of 38 cases of  MSRCT, there are 18 cases (47.36%) of non-Hodgkin lymphoma, 3 (7.89%) cases of Neuroblastoma,  3 (7.89%) cases of Synovial Sarcoma, 2 (5.26%) cases of Ewing Sarcoma, 2 (5.26%) cases of Undifferentiated neuroendocrine carcinoma,  2 (5.26%) case of Desmoplastic Small Round Cell Tumor, 1 (2.63%) case of  Primitive Neuroectodermal Tumor, 1 (2.63%) case of Amelanotic Melanoma (Small cell variant), 1 (2.63%)  case of  Anaplastic Dysgerminoma, 1 (2.63%)  case of Osteosarcoma, 1 (2.63 %) case of Wilm's tumor, 1 (2.63%)  case of  Dendritic cell Tumor Testis, 1 (2.63%) case of Undifferentiated Nasopharyngeal Carcinoma, 1 (2.63%) case of  Embryonal rhabdomyosarcoma.

Conclusions: IHC is very valuable tool for adequate and accurate categorization of MSRCT.



IHC, Malignant Small Round Cell Tumor, Non-Hodgkin Lymphoma

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