Oral pyogenic granuloma: one reactive hyperplastic lesion of the gingiva

Suryakanta Narendra, Chaitali Bose, Niranjan Rout


The term pyogenic granuloma refers to a disorder of the skin, oral mucosa and the gingiva, that usually presents as a solitary polypoid capillary hemangioma like growth often resulting from local irritation and trauma. It is manifested as an inflammatory response with similar characteristics to those of a granuloma. Different terminologies are used for this lesion by different investigators like, benign vascular tumor of pregnancy, granuloma pediculatum benignum, granuloma pyogenicum, Crocker and hartzell's disease. This lesion even if looks like a tumor, is non neoplastic in nature and present itself in various clinical and histological forms. Lack of association of pyogenic etiopathogenesis does not justify the use of terminology of pyogenic granuloma. In this article we are presenting a case series of pyogenic granuloma in different locations giving an insight into their myriad of etiologies and presenting the review of literature for its inclusion as one classified hyperplastic lesion of oral cavity.


Fibrous hyperplasia, Peripheral giant cell granuloma, Peripheral ossifying fibroma, Pyogenic granuloma, Reactive hyperplastic lesions

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Bhaskar SN,Jacoway JR. Pyogenic granuloma- Clinical features, incidence, histology, and the result of treatment. J Oral Surg. 1966;24:391-98.

Hullihen SP. Case of aneurism by anastomosis of the superior maxillae. Am J Dent Sci. 1844;4:160-2.

Vilmann A, Vilmann P, Vilmann H. Pyogenic granuloma evaluation of oral conditions. Br J Oral Maxillofac Surg. 1986;24:376-82.

Jafarzadeh H, Sanatkhani M, Mohtasham N. Oral pyogenic granuloma: A review. J Oral Sci. 2006;48:167-75.

Esmeili T, Lozada-Nur F, Epstein J. Common benign oral soft tissue masses. Dent Clin North Am. 2005;49:223-40.

da Silva AD, Silva CA, de Camargo Moraes P, Thomaz LA, Furuse C, de Ara├║jo VC. Recurrent oral pyogenic granuloma in port-wine stain. J Craniofac Surg. 2011;22:2356-58.

Ishida CE, Ramos-e-Silva M. Cryosurgery in oral lesions. Int J Dermatol. 1998;37:283-85.

Moon SE, Hwang EJ, Cho KH. Treatment of pyogenic granuloma by sodium tetradecyl sulfate sclerotherapy. Arch Dermatol. 2005;141(5):644-6.

Akamatsu T1, Hanai U, Kobayashi M, Miyasaka M. Pyogenic Granuloma: A Retrospective 10-year Analysis of 82 Cases. Tokai J Exp Clin Med. 2015(40):110-14.

Reddy V, Saxena S., Saxena S, Reddy M. Reactive hyperplastic lesions of the oral cavity: A ten year observational study on North Indian Population, J Clin Exp Dent. 2012 (4):e136-40.

Kashyap B, Reddy PS, Nalini P. Reactive lesions of oral cavity: A survey of 100 cases in Eluru, West Godavari district. Contemp Clin Dent. 2012;3(3):294-7.

Buchner A, Calderon S, Ramon Y. Localized hyperplastic lesions of the gingiva - A clinicopathological study of 302 lesions. J Periodontol. 1977;48:101-4.

Anneroth G, Sigurdson A. Hyperplastic lesions of the gingiva and alveolar mucosa. A study of 175 cases. Acta Odontol Scand. 1983;41(2):75-86.

Kfir Y, Buchner A, Hansen LS. Reactive lesions of the gingiva. A clinicopathological study of 741 cases. J Periodontol. 1980;51(11):655-61.

Gardner DG, Epulides in the dog: a review. J Oral Pathol Med. 1996;25(1):32-7.

Buchner A, Shnaiderman-Shapiro A, Vered M. Relative frequency of localized reactive hyperplastic lesions of the gingiva: a retrospective study of 1675 cases from Israel. J Oral Pathol Med. 2010;39(8):631-8.

Stablein MJ, Silverglade LB. Comparative analysis of biopsy specimens from gingiva and alveolar mucosa. J Periodontol. 1985;56(11):671-6.

Daley TD, Nartey NO, Wysocki GP. Pregnancy tumor: An analysis. Oral Surg Oral Med Oral Pathol. 1991;72:196-9.

Epivations A, Antoniades D, Zaraboukas T, Zairi E, Poulopoulos A, Kiziridou A, et al. Pyogenic granuloma of the oral cavity : Comparative study of its clinicopathological and immunohistochemical features. Pathol Int. 2005;55:391-7.

Mills SE, Cooper PH, Fechner RE. Lobular capillary hemangioma: the underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes. Am J Surg Pathol. 1980;4(5):470-79.