Carbimazol and acenocoumarol, where is the problem?

Naoual El Omri, Fadwa Mekouar, Rachid Eljaoudi, Mohamed Jira, Youssef Sekkach, Taoufik Amezyane, Driss Ghafir


Acenocoumarol and carbimazole are two drugs widely prescribed, they can sometimes be used in the same time. There is no known drug interaction between the two drugs but we report a case of a serious hemorrhagic complication following the concomitant use of the acenocoumarol and carbimazole. A 70-year old man treated by acenocoumarol for an aortic and mitral valve replacement. For a clinical and biological hyperthyroidism, he began treatment with carbimazole, ten days before admission. Three days later, he developed a mucocutaneous icterus with major hemorrhagic syndrome. The outcome was favourable after stopping medication and the use of vitamin K.


Acenocoumarol, Carbimazole, Drug interactions

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