A rare case of mixed connective tissue disease presenting with central nervous system glioma, vasculitis and polymyositis

Rushabh Parikh; Pushkar Ingale; Dhaval Dave; Manish Pendse; Smita Patil; Archana Bhate

doi:10.18203/2320-6012.ijrms20151472

Authors

Rushabh Parikh Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai
Pushkar Ingale Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai
Dhaval Dave Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai
Manish Pendse Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai
Smita Patil Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai
Archana Bhate Department of General Medicine, D Y Patil University School of Medicine, Navi Mumbai

DOI:

https://doi.org/10.18203/2320-6012.ijrms20151472

Keywords:

Mixed connective tissue disease, CNS glioma, Vasculitis, Polymyositis

Abstract

Mixed connective tissue disease (MCTD) was first recognized by Sharp and Colleagues in 1972 among a group of patients with overlapping clinical features of systemic lupus erythematosis (SLE), scleroderma and myositis, with the presence of distinctive antibodies against, what now is known to be U1-ribonucleoprotein (RNP). We report an unusual case of a 23-year old female with MCTD characterized by the coexistence of signs, symptoms and immunological features of 3 defined autoimmune diseases SLE, systemic sclerosis (SSc), polymyositis (PM) and an unusual presence of central nervous system (CNS) Glioma.

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