Morphometric analysis of corpus callosum in relation to brain size in fetuses of South Indian population

Vrinda Hari Ankolekar, Anne D Souza, Mamatha Hosapatna, Antony Sylvan D Souza

Abstract


Background: The corpus callosum (CC) comprises axons connecting the cortices of the two cerebral hemispheres and is the principal white matter fiber bundle in the brain Morphological characteristics of fetal corpus callosum are of value from embryologic and diagnostic points of view. Knowledge of fetal callosal size is an essential prerequisite for the study of its changes during infancy and childhood.

Methods: The study included twenty four formalin fixed fetuses ranging from 25 to 40 weeks obtained from department of Anatomy, Kasturba Medical College. The measurements taken were; frontal pole to occipital pole, anterior most point to posterior most point of CC, frontal pole of brain to anterior most point of CC, occipital pole of brain to posterior most point of CC, anterior edge of splenium to superior most point of superior colliculus and thickness of body of CC.

Results: Spearman’s correlation test was used to determine the correlation between different parameters. A strong positive correlation was found between the length and gestational age (r=0.69), between thickness and gestational age (r=0.4) and between length and thickness of corpus callosum (r=0.5).

Conclusions: Length and thickness of corpus callosum was found to increase proportionally to gestational age but it was not statistically significant. The growth of CC was proportional to the growth of brain. The precise anatomical knowledge regarding the morphology and growth of corpus callosum will provide baseline data for the diagnosis and assessment of progression of a disease affecting it.

 


Keywords


Corpus callosum, Fetuses, Splenium, Length, Thickness

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References


Bogen JE. The callosal syndromes. In: Heilman KM, Valenstein E, eds. Clinical neuropsychology. New York: Oxford UP; 1979: 308-359.

Aboitiz F, Scheibel AB, Fisher RS, Zaidel E. Fiber composition of the human corpus callosum. Brain Res. 1992;598:143-53.

Aboitiz F, Ide A, Olivares R. Corpus callosum morphology in relation to asymmetries in the postmortem human. In: Zaidel E, Iacoboni M, Pascual-Leone A, eds. Structure and function of the corpus callosum. Acase study in cognitive neuroscience. New York: MIT Press; 1999: 141-153.

Snell R. Clinical Neuroanatomy. 7 ed. London; Churchill Livingstone; 2000: 438.

Barkovich, A.J. and B.O. Kjos. Normal postnatal development of the corpus callosum as demonstrated by MR Imaging. AJNR 1988;9:487-91.

Byrd SE, Harwood-Nash DC, Fitz CR. Absence of the corpus callosum: computed tomographic evaluation in infants and children. J Can Assoc Radiol. 1978;29:108-12.

Hamilton WJ, Boyd JD, Mossman HW: Growth of Embryo and foetus; Development of external form; estimation of embryonic and fetal age. In: WJ Hamilton & HW Mossman eds. Human Embryology, Prenetal Development of form and function. 4th ed. England: Cambridge press; 1972: 172-177.

Ilayperuma I, Nanayakkara G, Palahepitiya N. Gross anatomical study on the gender differences in the corpus callosum. Galle Medical Journal. 2009;14(1):22-5.

Koshi R, Koshi T, Jeyaseelan L, Vettivel S. Morphology of corpus callosum in human foetuses. Clinical anatomy. 1997;10:22-6.

Bishop KM, Wahlsten D. Sex differences in the human corpus callosum: myth or reality? Neuroscience Biobehavioural Review. 1997;21:581-601.

Padmini MP, Rao BN. Sexual dimorphism of corpus callosum occurs in human foetuses. People’s journal of scientific research. 2012;5(1):15-8.

Anagnostopoulou S, Mourgela S, Katritsis D. Morphometry of corpus callosum: an anatomical study. Neuroanatomy. 2008;5:20-3.

Estruch R, Nicolas JM, Salmero M, Aragon C, Sacanella E, Fernandez-Sola J, Urbano- Marquez A. Atropy of the corpus callosum in chronic alcoholism. J. Neurol Sci. 1997; 148:145-51.