Prospective study of histopathological patterns of ovarian tumours in a tertiary care centre

A. Bhagyalakshmi, A. Sreelekha, S. Sridevi, J. Chandralekha, G. Parvathi, A. Venkatalakshmi


Background:Ovarian tumours account for 3% of all cancers amongst women, being the second most common cancer of the female genital tract. The ovarian tumours are highly heterogenous with a wide range of histological patterns. Aim of current study was to study the histological patterns and the age incidence of the ovarian tumours in our institute.

Methods:The present study is a prospective study conducted in the department of pathology, Andhra Medical College, from August 2011 to July 2013.

Results:We received a total of 267 specimens of ovarian tumours during this period, out of which, 263 were primary and 4 were secondary tumours. Benign tumours were 209 (78.3%), borderline were 10 (3.7%) and malignant were 48 (18%) in numbers. Overall surface epithelial tumours constituted the majority of tumours accounting for 214 (80.2%) cases, followed by germ cell tumours 38 (14.2%) and sexcord stromal tumours 11 (4.1%). The single most common tumour diagnosed was serous cystadenoma. The most common malignant tumour was serous cystadenocarcinoma. The age groups affected ranged from 11-70 years. The peak age incidences for different histological types were as follows: surface epithelial tumours: 21-50 years, germ cell tumours: 21-30 years, sexcord stromal tumours: 51-60years. Benign tumours were more common in 21-40 years of age, borderline in 31-50 years and malignant tumours in 41-50 years age group.

Conclusion:The results from our study were comparable with those reported in literature; however malignant serous and mucinous tumours showed a lower peak age incidence in our study. Krukenberg tumours also occurred in younger age group in our study.



Ovarian tumours, Histopathological patterns, Age groups

Full Text:



Lora Hedrick Ellenson, Edyta C. Pirog. The Female Genital Tract. In: Kumar, Abbas, Fausto, Aster, eds. Robbins and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia: Saunders; 2010: 1040.

World Health Organization. Classification of tumours. In: Tavassoli F. A., Devilee P eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. 5th ed. Lyon: IARC Press; 2003: 117.

Robert E. Scully, Philip B. Clement, Robert H. Young. Ovarian Surface Epithelial Stromal tumours. In: Stacey E. Mills, eds. Sternberg’s Diagnostic Surgical Pathology, 4th edition. Philadelphia: Lippincott William & Wilkins; 2004: 2543-2623.

Mondal SK, Banyopadhyay R, Nag DR, Roychowdhury S, Mondal PK, Sinha SK. Histologic pattern, bilaterality and clinical evaluation of 957 ovarian neoplasms: A 10-year study in a tertiary hospital of eastern India. J Can Res Ther. 2011;7(4):433-7.

S Kayastha. Study of ovarian tumours in Nepal medical college teaching hospital. Nepal Med Coll J. 2009;11(3):200-2.

Pilli GS, Suni KP, Dhaded AV, Yenni VV. Ovarian tumours: A study of 282 cases: J Indian Med Assoc. 2002;100:420-4.

Ameena Ashraf, A. Saeed Shaikh, Ayesha Ishfaq Abdullah Akram, Furrakh Kamal, Nazeefa Ahmad. The relative frequency and histopathological pattern of ovarian masses. Biomedica. 2012;2:98-102.

R Jha, S Karki. Histological pattern of ovarian tumors and their age distribution. Nepal Med Coll J. 2008;10(2):81-5.

N Gupta, D Bisht, Anil Kumar Agarwal, Veena K Sharma. Retrospective and prospective study of ovarian tumours and tumour-like lesions. Indian J Pathol Microbiol. 2007;50:525-7.

Sumaira Yasmin, Aiman Yasmin, Mohammad Asif. Clinicohistological pattern of ovarian tumours in Peshawar region. J Ayub Med Coll Abbottabad. 2008;20(4):11-3.

Bell DA, Scully RE. Ovary. In: Henson DE, Albores-Saveedra J, eds. The pathology of incipient neoplasia, 3rd ed. Philadelphia: WB Saunders; 1993: 419-440.

Kline RC, Wharton JT, Atkinson EN et al. Endometrioid carcinoma of the ovary: retrospective review of 145 cases. J Gynaecol Oncol. 1990;39:337-46.

World Health Organization. Classification of tumours. In: Tavassoli F. A., Devilee P eds. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. 5th ed. Lyon: IARC Press; 2003: 174.

Shen DH, Khoo US, Xue WC, Cheung AN. Ovarian mature cystic teratoma with malignant transformation. An interphase cytogenetic study. Int J Gynaecol Pathol. 1998;17(4):351-7.

Eisner RF, Nieberg RK, Berek JS. Synchronous primary neoplasms of the female reproductive tract. J Gynecol Oncol. 1989;33:335-9.

Zaino R, Whitney C, Brady MF, De Geest K, Burger RA, Buller RE. Simultaneously Detected endometrial and ovarian carcinoma - a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study. J Gynecol Oncol. 2001;83(2):355-62.

Juan Rosai. Female reproductive system. Juan Rosai, eds. In: Rosai and Ackerman’s Surgical Pathology. 10th ed. Gurgaon: Mosby Elsevier; 2011: 1581.

Zafrakas M, Venizelos ID, Theodoridis TD, Zepiridis L, Agorastos T, Bontis JN. Virilizing ovarian hilus (Leydig) cell tumor with concurrent contralateral hilus cell hyperplasia: a rare diagnosis. Eur J Gynaecol Oncol. 2009;30(3):338-40.