Study of insulin resistance and antioxidant vitamin status in prostate cancer patients

Authors

  • S. Prasanth Vardhan Department of Department of Biochemistry, Narayana Medical College, Nellore - 524003, Andhra Pradesh
  • M. Krishnamma Department of Department of Biochemistry, Narayana Medical College, Nellore - 524003, Andhra Pradesh
  • J. N. Naidu Department of Department of Biochemistry, Narayana Medical College, Nellore - 524003, Andhra Pradesh
  • M. Prasad Naidu Department of Department of Biochemistry, Narayana Medical College, Nellore - 524003, Andhra Pradesh

Keywords:

Prostate cancer, Insulin resistance, Antioxidant vitamin, Hyperinsulinemia

Abstract

The incidence of prostate cancer is 5 per 100000 in southern and eastern Asia. Both genetic and environmental factors have been implicated in its etiology. The mitogenic and growth stimulatory effects of Insulin growth factor may be involved in prostate carcinogenesis. To evaluate serum insulin and insulin resistance was passed by HOMA- IR. Prostatic specific antigen passed by immune-enzymatic assay. Vitamins were estimated by high performance liquid chromatography. In our study 30 prostate cancer patients aged 60-80years were taken as cases. 30 normal age matched disease free person were taken as controls in both groups, Insulin resistance and antioxidant vitamin status was studied.  In the present study, the value of HOMA-IR was (P <0.05) is significantly higher compare to controls. Serum vitamin E and vitamin C values for cases was reduced (P <0.05) significantly lower than controls. The development of prostate cancer is a multistep process. Hyperinsulinemia associated with insulin resistance may play a role in pathogenesis of prostate cancer. Prostate cancer cells generate high levels a ROS.

References

Paolo Boffetla, Paul Brennan, Rodolfo Saracci. Neoplasms. In: Walter W. Holland, Roger Detels, George Knox, eds. Oxford Text Book of Public Health. 4th ed. UK: Oxford University Press; 2004: 1155-1192.

Arthur A. Caire, Leon Sun, Thomas J. Polascik, David M. Albala, Judd W. Mouobese. African-Americans with have higher-risk pathological features and a greater risk of PSA recurrence than non-African Americans: BJUI Int. 2010 Oct;106(8):1157-60.

Ross, Ronald K. Molecular determinants of prostate cancer progression across race-ethnicity. University of Southern California Los Angeles, 2004:1-23.

Mhairi G. MacDonald, Mary M. K. Seshia, Martha D. Mullett. Internal medicine hyperplastic and malignant diseases of the prostate. In: Kaplan, George W., Irene M. McAleer, eds. Avery’s Neonatology. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2005: 543-553.

Ann W. Hsing, Yu-Tang Gao, Streamson Chua, Jr., Jie Deng, Frank Z. Stanczyk. Insulin resistance and prostate cancer risk. J National Cancer Inst. 2003 Jan;95:1.

Binod Kumar, Sweaty Koul, Lakshmipathi Khandrika, Randall B. Meacham, and Hari K. Koul. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res. 2008 Mar;68(6):1777-86.

Endres DB, Rude RK. Mineral and bone metabolism. In: Burtis CA, Ashwood ER, Bruns DE, eds. Tietz Textbook of Clinical Chemistryand Molecular Diagnostics. 4th ed. St. Louis Missouri, USA: Elsevier Saunders; 2006: 1891-1965.

Cox Michael E., Martin E. Gleave, Mahvash Zakikhani, Robert H. Bell, Esther Piura, Elaine Vickers, Matthew Cunningham, Ola Larsson, Ladan Fazli, Michael Pollak. Insulin receptor expression by human prostate cancers. The Prostate. 2009;69(1):33-40.

Nandeesha, Hanumanthappa. Insulin: a novel agent in the pathogenesis of prostate cancer. Int Urol Nephrol. 2009;41(2):267-72.

Burton, Anya J., Kate M. Tilling, Jeff M. Holly, Freddie C. Hamdy, Mari-Anne E. Rowlands, Jenny L. Donovan, and Richard M. Martin. Metabolic imbalance and prostate cancer progression. Int J Molecul Epidemiol Gene. 2010;1(4):248.

Zhang W, Hu R. Why does diabetes offer protective effects against prostate cancer? The possible role of its microvascular complications. Med Hypotheses. 2010 Jul;75(1):134-5.

Pneumothorax, Primary Spontaneous. Function of lipid soluble vitamins. Kuwait Med J. 2009;41(1):642-52.

Sandhya, B. et al. Lipid peroxidation and antioxidant status in prostate cancer patients. Indian J Sci Technol. 2010;3(1):83-6.

Ambrosini G. L. et al. Fruit, vegetable, vitamin A intakes, and prostate cancer risk. Prostate Cancer Prostatic Dis. 2007;11(1):61-6.

Dwivedi, V. K. et al. Fixed dose combination of ceftazidime plus tobramycin acts as free radical scavenger in liver of mus musculus mice. Current Enzyme Inhi. 2009;5(3):171-5.

Strimpakos, Alex S. et al. The role of mTOR in the management of solid tumors: an overview. Cancer Treat Rev. 2009;35(2):148-59.

Downloads

Published

2017-01-23

How to Cite

Vardhan, S. P., Krishnamma, M., Naidu, J. N., & Naidu, M. P. (2017). Study of insulin resistance and antioxidant vitamin status in prostate cancer patients. International Journal of Research in Medical Sciences, 2(2), 643–646. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2213

Issue

Section

Original Research Articles