Imidacloprid poisoning: a modern foe
Keywords:
Imidacloprid poisoning, Government medical college, PatialaAbstract
Imidacloprid is a relatively new insecticide in the chloronicotinyl nitroguanidine class. Imidacloprid has a wide variety of uses; it is used on cotton and vegetable crops, turf grass and ornamental plant products, in indoor and outdoor cockroach control products and in termite control products. Imidacloprid acts as a competitive inhibitor at nicotinic acetylcholine receptors in the nervous system resulting in impairment of normal nerve function. Scientific literature on human imidacloprid poisoning has been relatively sparse. We report three subjects who presented with imidacloprid poisoning.
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References
U. S. EPA Office of Pesticide Programs. Pesticide fact sheet. Imidacloprid. 1994;18:1.
Tomlin CDS. The pesticide manual, a world compendium. In: Tomlin CDS, eds. British Crop Protection Council. 14th ed. Surry, England: British Crop Protection Council; 2006: 598-599.
Buckingham SD, Lapied B, Corronc HL, Grolleau F, Sattelle DB. Imidacloprid actions on insect neuronal acetylcholine receptors. J Exp Biol. 1997;200:2685-92.
Matsuda K, Sattelle DB. Mechanism of selective actions of neonicotinoids on insect acetylcholine receptors. In: Clark JM, Ohkawa H, eds. New Discoveries in Agrochemicals: American Chemical Society Symposium Series. 3rd ed. Oxford, UK: Oxford University Press; 2005: 172-183.
Schroeder ME, Flattum RF. The mode of action and neurotoxic properties of the nitroethylene heterocycle insecticides. Pestic Biochem Physiol. 1984;22:148-60.
Sheets LP. Imidacloprid: a neonicotinoid insecticide. In: Krieger RI, eds. Handbook of Pesticide Toxicology. 2nd ed. San Diego, CA: Academic Press; 2001: 1123-1130.
Tomizawa M, Casida JE. Minor structural changes in nicotinic insecticides confer differential subtype selectivity for mammalian nicotinic acetylcholine receptors. Br J Pharmacol. 1999;127(1):115-22.
Zwart R, Marga O, Henk PM. Nitromethylene heterocycles: selective agonists of nicotinic receptors in locust neurons com- pared to mouse N1E-115 and BC3H1 cells. Pest Biochem Physiol. 1994;48:202-13.
Wu I, Lin J, Cheng E. Acute poisoning with the neonicotinoid insecticide imidacloprid in N-methyl pyrrolidone. Clin Toxicol. 2001;39(6):617-21.
Shadnia S, Moghaddam HH. Fatal intoxication with imidacloprid insecticide. Am J Emerg Med. 2008;26(5):634.
Doull J. Toxic effect of pesticides. In: Doull J, CD Klassen, MO Amdur, eds. Cassarett and Doull’s Toxicology: The Basic Science of Poisons. 4th ed. NY: Pergamon Press; 1991: 889-893.
Mohamed F, Gawarammana I, Robertson TA, Roberts MS, Palangasinghe C et al. Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide. PLoS One. 2009;4:e5127.
Agarwal R, Srinivas R. Severe neuropsychiatric manifestations and rhabdomyolysis in a patient with imidaclopride poisoning. Am J Emerg Med. 2007;25:844-5.
