Alveolar rhabdomyosarcoma in children with histomorphological review

Authors

  • S. K. Nema Department of Pathology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh
  • Arjun Singh Department of Pathology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh
  • Honey Bhasker Department of Pathology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh
  • Pawan Bhambani Department of Pathology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh
  • H. S. Sharma Department of Otolaryngology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh
  • Kumud Julka Department of Radiology, Index Medical College Hospital and Research Centre, Indore, Madhya Pradesh

Keywords:

Alveolar rhabdomyosarcoma (ARMS), Primitive neuroectodermal tumor (PNET), Immunohistochemistry (IHC), Fine needle aspiration cytology (FNAC)

Abstract

Rhabdomyosarcomas (RMS) are aggressive malignant neoplasm of mesenchymal origin, related to skeletal muscle lineage. These are the most common soft tissue tumors in children. The diagnosis is made by microscopic analysis and ancillary techniques like immunohistochemistry, electron microscopy, cytogenetics and molecular biology. We encountered a case of a 03 years old child who presented with a tender, reddish, soft swelling over cheek for three weeks. The FNAC was reported as a small round cell tumor, Probably Primitive Neuroectodermal Tumor (PNET). The biopsy of tumor revealed a small round cell tumor with an alveolar pattern. Tumor giant cells were absent and mitotic figures were infrequent. Hence, differentials of alveolar rhabdomyosarcoma and PNET were rendered. Immunohistochemistry (IHC) demonstrated desmin positivity. Thus, a final diagnosis of alveolar rhabdomyosarcoma was offered.

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Published

2017-01-23

How to Cite

Nema, S. K., Singh, A., Bhasker, H., Bhambani, P., Sharma, H. S., & Julka, K. (2017). Alveolar rhabdomyosarcoma in children with histomorphological review. International Journal of Research in Medical Sciences, 2(2), 775–778. Retrieved from https://www.msjonline.org/index.php/ijrms/article/view/2245

Issue

Section

Case Reports