Clinical profile and factors determining outcome of intramural very low birth weight babies in a tertiary care centre: a retrospective study

Devi Meenakshi K., Arasar Seeralar A. T., Srinivasan Padmanaban


Background: Very low birth weight (VLBW) babies are at increased risk of a number of complications both immediate and late. Worldwide it has been observed that these babies contribute to a significant extent to neonatal mortality and morbidity. Aim of the study was to study the risk factors contributing to mortality in VLBW babies and to evaluate the morbidity pattern in these infants.

Methods: A retrospective analysis of data retrieved from the case records of VLBW babies admitted in the NICU of Kilpauk Medical College between January 2015 to December 2015. Out of the 2360 intramural babies admitted during the study period, 99 babies were less than 1500 gms. The risk factors for these babies were analyzed for their association with the outcome. Data were statistically analyzed.

Results: In present study, we found that sex of the baby, gestational age, obstetric score, birth asphyxia, pulmonary haemorrhage, ROP and presence of shock were found to be associated with increased mortality. By logistic regression analysis it was observed that birth weight of the baby (p value 0.002), duration of stay (p value 0.0006), presence of shock (p<0.0001), were the risk factors significantly associated with poor outcome.

Conclusions: Among the maternal and neonatal factors analyzed in the study using logistic regression analysis, birth weight, duration of hospital stay and presence of shock were significantly related to poor outcome. Of these presence of shock was the single most important factor that predicted increased mortality.


Morbidity pattern, Mortality, VLBW

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Roy KK, Baruah J, Kumar S, Malhotra N, Deorari AK, Sharma JB. Maternal antenatal profile and immediate neonatal outcome in VLBW and ELBW babies, Indian J Pediatr. 2006;73(8):669-73.

Mannan MA, Jahan N, Dey SK, Uddin MF, Ahmed S. Maternal and foetal risk factor complication with immediate outcome during hospital stay of very low birth weight babies. Mymensingh Med J. 2012;21(4)639-47.

Tsou KI, Tsao PN. Taiwan Infant Development Collaborative Study Group. The morbidity and survival of very-low-birth-weight infants in Taiwan. Acta Paediatr Taiwan. 2003;44(6):349-55.

Hazzani FA, Al-Alaiyan S, Hassanein J, Khadawardi E. Short-term outcome of very low-birth-weight infants in a tertiary care hospital in Saudi Arabia, Ann Saudi Med. 2011;31(6):581-5.

Acharya N, Mishra P, Shrestha N, Gupta V. Immediate Outcome of VLBW And ElBW Babies in a Tertiary Care Center of Nepal. J Nepal gunj Med Coll. 2014;12(1):32-4.

Naskar N, Swain A, Das KD, Patnayak AB. Maternal Risk Factors, Complications and Outcome of Very Low Birth Weight Babies: Prospective Cohort Study from a Tertiary Care Centre in Odisha. J Neonatal Biol. 2014,3:142.

Yang CY, Lien R, Yang PH, Chu SM, Hsu JF, Fu RH, et al. Analysis of incidence and risk factors of Retinopathy of prematurity among Very Low Birth weight infants in North Taiwan. Pediatrics and Neonatology. 2011;52,:321-6.

Mohapatra SK, Mishra AK. Outcome of very low birth weight babies (VLBW) in Level II care nursery, Research. 2015;2:1464.

Obstetric Factors Influencing the Outcome of VLBW Babies Admitted to Level 3 Malaysian nurseries, Neonatal Data Collection Group, Malaysian Paediatric Association, clo Damansara Specialist Hospital, 47400 Petaling Jaya, Malaysia, Med J Malaysia. 1998;53(2):153-60.

Poudel P, Budhathoki S, Shrivastava MK. Maternal Risk Factors and Morbidity pattern of very low birth weight infants: A NICU based study at Eastern Nepal, J Nepal Paediatr, Soc. 2009;29(2):59-66.

Vidyasagar V, Venugopal B. Survival and outcome parameters of VLBW infants in a tertiary care hospital. J of Evidence Based Med & Hlth care 2015;2(36):5688-703.